{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:11:34Z","timestamp":1758924694462},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T00:00:00Z","timestamp":1331683200000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the levels of placental growth factor (PlGF) in second trimester maternal serum in trisomy 21 cases and euploid controls \u2013 an unclear subject in the published literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Second trimester maternal serum samples from 17 recent (since 2005) and 74 older trisomy 21 cases and 542 euploid controls were extracted from frozen storage and retrospectively analysed for PlGF using a DELFIA Xpress immunoassay platform. Results were converted to multiples of median (MoM) for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The control group had a PlGF MoM of 0.99, the recent trisomy 21 cases had a PlGF MoM of 1.13 and the older cases a PlGF MoM of 1.11; however, the differences between trisomy 21 cases and controls were not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although we have found no significant change in the second trimester levels of PlGF in trisomy 21 pregnancies, there remains wide disagreement within the literature on the behaviour of this marker during pregnancies of this syndrome. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.2904","type":"journal-article","created":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T13:18:23Z","timestamp":1331731103000},"page":"117-121","source":"Crossref","is-referenced-by-count":2,"title":["Maternal serum placental growth factor in second trimester trisomy 21 pregnancies"],"prefix":"10.1002","volume":"32","author":[{"given":"N. J.","family":"Cowans","sequence":"first","affiliation":[{"name":"Prenatal Screening Unit, Department of Clinical Biochemistry King George Hospital  Barley Lane Goodmayes, Essex United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Kisanga","sequence":"additional","affiliation":[{"name":"Prenatal Screening Unit, Department of Clinical Biochemistry King George Hospital  Barley Lane Goodmayes, Essex United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Prenatal Screening Unit, Department of Clinical Biochemistry King George Hospital  Barley Lane Goodmayes, Essex United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.20.9267"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(97)90007-2"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod56.2.489"},{"key":"e_1_2_5_5_1","first-page":"517","article-title":"Placenta growth factor\u20101 is chemotactic, mitogenic, and angiogenic","volume":"76","author":"Ziche M","year":"1997","journal-title":"Lab Invest"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)47298-5"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6244"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2496"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2143"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.113129"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.148"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6331"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8890"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8881"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.218"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/7.8.765"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.998"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02246.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6486.1940"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456329202900504"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.77.11.1435"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4347"},{"key":"e_1_2_5_23_1","article-title":"Maternal active smoking and newborn body composition","author":"Samper MP","year":"2011","journal-title":"Early Hum Dev"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199803)18:3<225::AID-PD239>3.0.CO;2-B"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.13.7717"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780050"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17189"},{"issue":"12","key":"e_1_2_5_28_1","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/pd.2894","article-title":"Stability of first trimester Placental Growth Factor (PlGF) in serum and whole blood","volume":"32","author":"Cowans NJ","year":"2011","journal-title":"Prenat Diagn"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767051003678242"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2904","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.2904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T17:06:34Z","timestamp":1698685594000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.2904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1002\/pd.2904"],"URL":"https:\/\/doi.org\/10.1002\/pd.2904","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}