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However, new vascular territories, such as the anterior and posterior cerebral arteries, might provide additional information on the onset of the brain sparing effect. The fractional moving blood volume estimation and three\u2010dimensional power Doppler ultrasound indices are new techniques that seem to be promising in indentifying cases at earlier stages of vascular deterioration; still, they are not available for clinical application and more information is needed on the reproducibility and advantages of three\u2010dimensional power Doppler ultrasound blood flow indices. In the past, the brain sparing effect was considered as a protective mechanism; however, recent information challenges this concept. There is growing evidence of an association between brain sparing effect and increased risk of abnormal neurodevelopment after birth. Even in mild late\u2010onset intrauterine growth restriction affected fetuses with normal umbilical artery blood flow, increased cerebral blood perfusion can be associated with a substantial risk of abnormal neuroadaptation and neurodevelopment during childhood. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.2913","type":"journal-article","created":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T13:18:23Z","timestamp":1331731103000},"page":"103-112","source":"Crossref","is-referenced-by-count":54,"title":["Can anomalies of fetal brain circulation be useful in the management of growth restricted fetuses?"],"prefix":"10.1002","volume":"32","author":[{"given":"Edgar","family":"Hernandez\u2010Andrade","sequence":"first","affiliation":[{"name":"Maternal Fetal Medicine Department National Institute of Perinatology  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus Andres","family":"Benavides 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