{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T11:15:49Z","timestamp":1700392549098},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,3,27]],"date-time":"2002-03-27T00:00:00Z","timestamp":1017187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Maternal serum markers for trisomy 21 screening (MSS) can be assayed in women \u226535\u2009years in an attempt to reduce the need for invasive procedures and thereby avoid their side effects. Our objective was to compare, in women \u226535, eight different software packages dedicated to second trimester MSS, thus providing reliable data for patient counselling. A simulation study was carried out on 189 sera from women with Down syndrome fetuses and 11\u2009962 sera from mothers of unaffected babies. The first step was to estimate the joint distribution of alpha\u2010fetoprotein (AFP) and free beta\u2010human chorionic gonadotrophin (\u03b2\u2010hCG). The second step was to calculate trisomy 21 detection and false\u2010positive rates for each software according to maternal age (35\u201345\u2009years), using the usual 1:250 risk threshold. Agreement between software packages was measured using 2\u00d72\u2009kappa coefficients. Detection rates and false\u2010positive rates increased with maternal age. Depending on the software, 57\u201371% detection rates were achieved at 35\u2009years with 12\u201318% false\u2010positive rates. At 45\u2009years, 61\u2013100% detection rates were achieved with 66\u201395% false\u2010positive rates. Up to 39\u2009years, all softwares were concordant (kappa coefficients &gt;0.75). In the range 35\u201345\u2009years, false\u2010positive and detection rates increased substantially with maternal age and differences between software packages are observed. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.292","type":"journal-article","created":{"date-parts":[[2004,6,30]],"date-time":"2004-06-30T16:02:40Z","timestamp":1088611360000},"page":"350-353","source":"Crossref","is-referenced-by-count":10,"title":["Detection and false\u2010positive rates of maternal serum markers for Down syndrome screening according to maternal age in women over 35\u2009years of age. A study of the agreement of eight dedicated software packages"],"prefix":"10.1002","volume":"22","author":[{"given":"Fran\u00e7oise","family":"Muller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Christophe","family":"Thalabard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Dommergues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,3,27]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"La Situation D\u00e9mographique en 1997. 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