{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:46:33Z","timestamp":1778683593565,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T00:00:00Z","timestamp":1331683200000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Earlier studies have shown that maternal hormone secretion during late first or second trimester may be affected by gravidity. We examined the luteoplacental hormone secretion during 5\u201311\u2009weeks of gestation in relation to gravidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Forty\u2010one naturally conceived pregnancies underwent weekly assessment of serum human chorionic gonadotrophin, progesterone and 17\u2010OH progesterone, estradiol, testosterone, and pregnancy\u2010associated plasma protein A levels. In addition, the volume and the vasculature of the dominant ovary with corpus luteum were assessed with the use of a 3\u2010dimensional power Doppler ultrasonography. Areas under the curve for hormonal and ultrasonographic parameters were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two out of the 41 women were pregnant for the first time. All the pregnancies were uncomplicated and resulted in term deliveries of appropriately grown newborns. During pregnancy weeks 5\u201311, the secretion (area under the curve) of human chorionic gonadotrophin (6.54\u2009\u00b1\u20090.03 vs 6.39\u2009\u00b1\u20090.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.010), progesterone (3.49\u2009\u00b1\u20090.02 vs 3.36\u2009\u00b1\u20090.03, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), and 17\u2010OH progesterone (2.73\u2009\u00b1\u20090.03 vs 2.62\u2009\u00b1\u20090.03, <jats:italic>p<\/jats:italic>\u2009=\u20090.013) were higher in primigravid than in multigravid women. No other differences were detected between primigravid and multigravid women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The placental function already differs between primigravid and multigravid women during the first weeks of pregnancy, which reflects the corpus luteal function. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.2921","type":"journal-article","created":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T13:18:23Z","timestamp":1331731103000},"page":"160-167","source":"Crossref","is-referenced-by-count":16,"title":["Effect of parity and fetal sex on placental and luteal hormones during early first trimester"],"prefix":"10.1002","volume":"32","author":[{"given":"Ilkka Y.","family":"J\u00e4rvel\u00e4","sequence":"first","affiliation":[{"name":"Departments of Obstetrics and Gynecology Oulu University Hospital  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"\u017d\u00e1\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Institute for the Care of Mother and Child Department of IVF Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4ivi","family":"Laitinen","sequence":"additional","affiliation":[{"name":"Laboratory Oulu University Hospital  Oulu Finland"},{"name":"Clinical Laboratory Central Ostrobothnia Hospital  Kokkola Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku","family":"Ryyn\u00e4nen","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology Oulu University Hospital  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aydin","family":"Tekay","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology Oulu University Hospital  Oulu 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