{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:43:47Z","timestamp":1782391427265,"version":"3.54.5"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T00:00:00Z","timestamp":1332115200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,3]]},"abstract":"ABSTRACT<\/jats:title>Objective<\/jats:title>This study aims to investigate the length and shape of the nasal bones in fetuses with trisomy 21 at 16\u201324\u2009weeks' gestation.<\/jats:p><\/jats:sec>Method<\/jats:title>We acquired three\u2010dimensional volumes of the fetal profile from 41 fetuses with trisomy 21. The multiplanar mode was used to measure nasal bone length in the exact midsagittal plane and in parasagittal and oblique views of the fetal face and to examine the nasal bones in the coronal plane.<\/jats:p><\/jats:sec>Results<\/jats:title>There was bilateral absence of the nasal bones in 11 (26.8%) cases and unilateral absence in one (2.4%). In 29 (70.7%) cases with present nasal bones, there was progressive over\u2010estimation of nasal bone length when measured in parasagittal and oblique views compared to measurements taken in the exact midsagittal plane. In the coronal plane, in 18 of 29 (62.1%) fetuses with trisomy 21, the nasal bones were divergent, whereas in 131 of 135 (97.0%) euploid fetuses, the bones were entirely fused in the midline.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Parasagittal and oblique scanning planes may produce over\u2010estimation of nasal bone length in trisomy 21 fetuses because they often have divergent nasal bones. Consequently, it is essential that measurement of nasal bone length is carried out in the exact midsagittal plane of the face. \u00a9 2012 John Wiley & Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.2938","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T11:00:04Z","timestamp":1332154804000},"page":"240-244","source":"Crossref","is-referenced-by-count":12,"title":["Nasal bone assessment in fetuses with trisomy 21 at 16\u201324\u2009weeks of gestation by three\u2010dimensional ultrasound"],"prefix":"10.1002","volume":"32","author":[{"given":"Nicola","family":"Persico","sequence":"first","affiliation":[{"name":"Department of Fetal Medicine King's College Hospital London UK"},{"name":"Department of Obstetrics and Gynecology 'L. Mangiagalli' Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Molina","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine Unit, Department of Obstetrics and Gynecology San Cecilio University Hospital (HUSC) and University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Azumendi","sequence":"additional","affiliation":[{"name":"Unidad de Ecografia Centro Gutenberg Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Fedele","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology 'L. Mangiagalli' Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kypros H.","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine King's College Hospital London UK"},{"name":"Department of Fetal Medicine University College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06709-5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000250903.17964.87"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.11.042"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7745"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5404"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.984"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1885"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1805"},{"key":"e_1_2_5_11_1","first-page":"124","article-title":"The prenatal development of the human nasal and vomeral bones","volume":"14","author":"Sandikcioglu M","year":"1994","journal-title":"J Craniofac Genet Dev Biol"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2938","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2938","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.2938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T13:30:49Z","timestamp":1698672649000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.2938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1002\/pd.2938"],"URL":"https:\/\/doi.org\/10.1002\/pd.2938","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}