{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:42:52Z","timestamp":1788352972908,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T00:00:00Z","timestamp":1332115200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This paper aimed to determine the feasibility of identification and measurement reproducibility of intracranial translucency (IT) in our population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective study in which five accredited operators attempted to identify and measure the IT during first\u2010trimester sonographic screening for aneuploidy in 990 fetuses. The presence or absence of spina bifida was determined at the time of the second\u2010trimester scan or after birth. Measurement reproducibility was assessed through intraclass correlation coefficient (ICC) on a subgroup of 150 fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Identification and measurement of the IT were possible in 961 (97%) cases. The mean IT anteroposterior diameter was 1.8\u2009mm (SD\u2009\u00b1\u20090.37; range 0.8\u20133.1), and the size increased linearly with advancing gestation (IT\u2009=\u20090.74\u2009+\u20090.02\u2009\u00d7\u2009crown\u2013rump length; <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.15, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The only fetus with spina bifida in this series presented with absent IT. Intra\u2010observer and inter\u2010observer ICCs were 0.79 and 0.75, respectively (95% confidence intervals 0.72\u20130.84 and 0.67\u20130.81, respectively; both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The IT increases linearly with increasing crown\u2013rump length and seems to be of value in the first\u2010trimester detection of spina bifida. It is easy to identify and measure and shows excellent intra\u2010observer and inter\u2010observer reproducibility measurements. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.2944","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T11:00:04Z","timestamp":1332154804000},"page":"259-263","source":"Crossref","is-referenced-by-count":21,"title":["Intracranial translucency at 11\u201313\u2009weeks of gestation: prospective evaluation and reproducibility of measurements"],"prefix":"10.1002","volume":"32","author":[{"given":"Bego\u00f1a","family":"Adiego","sequence":"first","affiliation":[{"name":"Delta Ultrasound Center in Obstetrics and Gynecology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Illescas","sequence":"additional","affiliation":[{"name":"Delta Ultrasound Center in Obstetrics and Gynecology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Martinez\u2010Ten","sequence":"additional","affiliation":[{"name":"Delta Ultrasound Center in Obstetrics and Gynecology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmina","family":"Bermejo","sequence":"additional","affiliation":[{"name":"Gabinete Medico Velazquez  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Perez\u2010Pedregosa","sequence":"additional","affiliation":[{"name":"Delta Ultrasound Center in Obstetrics and Gynecology  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Wong","sequence":"additional","affiliation":[{"name":"Fetal Medicine Center, Fetal Medicine Interest Group GIMEF  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldo","family":"Sepulveda","sequence":"additional","affiliation":[{"name":"Fetal Medicine Center, Fetal Medicine Interest Group GIMEF  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,19]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"76","volume-title":"World Atlas of Birth Defects","author":"International Centre for Birth Defects","year":"2003"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91610-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3865"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10060403.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2642"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7329"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7552"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11280-6"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.090"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8994"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2011.30.12.1643"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2608"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8363"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2832"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2632"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2944","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2944","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.2944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T13:31:06Z","timestamp":1698672666000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.2944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1002\/pd.2944"],"URL":"https:\/\/doi.org\/10.1002\/pd.2944","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}