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The measurement of fetal NT thickness at the 11\u201314\u2010week scan has been combined with maternal age to provide an effective method of screening for trisomy 21; for an invasive testing rate of 5%, about 75% of trisomic pregnancies can be identified. When maternal serum free\u2010\u03b2 human chorionic gonadotrophin (\u03b2\u2010hCG) and pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A) at 11\u201314\u2009weeks are also taken into account, the detection rate of chromosomal defects is about 90%. Increased NT can also identify a high proportion of other chromosomal abnormalities and is associated with major defects of the heart and great arteries, and a wide range of skeletal dysplasias and genetic syndromes. In monochorionic twins, discordancy for increased NT is an early marker of twin\u2010to\u2010twin transfusion syndrome (TTTS). As with the introduction of any new technology into routine clinical practice, it is essential that those undertaking the 11\u201314\u2010week scan are adequately trained and their results are subjected to rigorous audit. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.308","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:24:15Z","timestamp":1030303455000},"page":"308-315","source":"Crossref","is-referenced-by-count":147,"title":["Increased fetal nuchal translucency at 11\u201314\u2009weeks"],"prefix":"10.1002","volume":"22","author":[{"given":"Kypros H.","family":"Nicolaides","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Heath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Cicero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4,22]]},"reference":[{"issue":"1","key":"e_1_2_1_2_1","first-page":"69","article-title":"First\u2010trimester diagnosis of fetal congenital heart disease by transvaginal ultrasonography","volume":"84","author":"Achiron R","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_3_1","unstructured":"BowerS ChittyL BewleyS et al.1995.First trimester nuchal translucency screening of the general population: data from three centres (Abstract). 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