{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:40:07Z","timestamp":1772970007974,"version":"3.50.1"},"reference-count":77,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,4,22]],"date-time":"2002-04-22T00:00:00Z","timestamp":1019433600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Congenital anomalies of the central nervous system (CNS) are among the most frequent malformations. Current ultrasound equipment can give a precise diagnosis of many of these lesions from early gestation. High\u2010resolution transvaginal probes play a major role both in allowing an early diagnosis and for better defining subtle details of both normal and abnormal cerebral anatomy. The diagnostic accuracy of prenatal ultrasound is, however, heavily dependent upon the expertise of the sonologist, the type of equipment employed, and the time dedicated to the scan. Fetal sonography is effective in identifying neural tube defects, although alpha\u2010fetoprotein screening seems to give a greater sensitivity. The accuracy of ultrasound in the identification of CNS malformations other than neural tube defects remains unclear because of the ascertainment biases of the few large prospective studies that have been conducted to date. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.310","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:24:15Z","timestamp":1030317855000},"page":"321-330","source":"Crossref","is-referenced-by-count":49,"title":["Sonography of fetal cerebrospinal anomalies"],"prefix":"10.1002","volume":"22","author":[{"given":"Gianluigi","family":"Pilu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Hobbins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,4,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1991.01050336.x"},{"issue":"2","key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0029-7844(96)00506-6","article-title":"Cerebral lateral ventricular asymmetry: is this a normal ultrasonographic finding in the fetal brain?","volume":"89","author":"Achiron R","year":"1997","journal-title":"Obstet Gynecol"},{"issue":"3","key":"e_1_2_1_4_1","first-page":"214","article-title":"The clinical significance of measurement microcephaly","volume":"123","author":"Avery GB","year":"1972","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.166.2.8553961"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.153.6.1289"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/jnen\/13.1.14","article-title":"The Dandy\u2010Walker syndrome or the so\u2010called atresia of the foramen Magendie","volume":"13","author":"Benda CE","year":"1954","journal-title":"J Neuropathol Exp Neurol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.199.2.8668792"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1994.04030183.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.05030151.x"},{"key":"e_1_2_1_11_1","first-page":"637","article-title":"A clinical and genetical study of microcephaly","volume":"57","author":"Book JA","year":"1957","journal-title":"Am J Ment Defic"},{"issue":"4","key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.7863\/jum.1995.14.4.303","article-title":"Difficulties in the prenatal diagnosis of microcephaly","volume":"14","author":"Bromley B","year":"1995","journal-title":"J Ultrasound Med"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.3.7972820"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870190409"},{"issue":"1","key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1399-0004.1979.tb00848.x","article-title":"Recurrence risks for congenital hydrocephalus","volume":"16","author":"Burton BK","year":"1979","journal-title":"Clin Genet"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)92273-8"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.169.3.3055034"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(84)90027-9"},{"issue":"6","key":"e_1_2_1_19_1","first-page":"908","article-title":"A prospective study of the accuracy of ultrasound in predicting fetal microcephaly","volume":"69","author":"Chervenak FA","year":"1987","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.22.6.634"},{"key":"e_1_2_1_21_1","first-page":"431","volume-title":"Handbook of Clinical Neurology","author":"DeMyer W","year":"1977"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.185.3.1438757"},{"issue":"12","key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1056\/NEJM199309163291201","article-title":"Effect ofprenatal ultrasound screening on perinatal outcome (see Comments)","volume":"329","author":"Ewigman BG","year":"1996","journal-title":"N Engl J Med"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.151.2.6709918"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.172.2.2664864"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.181.1.1887016"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.188.1.7685528"},{"issue":"4","key":"e_1_2_1_28_1","first-page":"588","article-title":"Sonographic development of the normal developmental anatomy of fetal cerebral ventricles. I. The frontal horns","volume":"72","author":"Goldstein I","year":"1988","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999452"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70577-6"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.12040276.x"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970150402"},{"issue":"10","key":"e_1_2_1_33_1","first-page":"716","article-title":"Management of apparently isolated fetal ventriculomegaly. (Review)","volume":"49","author":"Gupta JK","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_34_1","first-page":"1014","volume-title":"Neuroradiology in Infants and Children","author":"Harwood Nash DC","year":"1976"},{"issue":"3","key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.7863\/jum.1991.10.3.121","article-title":"Effect of measurement errors on sonographic evaluation of ventriculomegaly","volume":"10","author":"Heiserman J","year":"1991","journal-title":"J Ultrasound Med"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.61.3.0515"},{"issue":"6","key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1542\/peds.78.6.1064","article-title":"Computed tomography of the head in the evaluation of microcephaly","volume":"78","author":"Jaworski M","year":"1986","journal-title":"Pediatrics"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.09010014.x"},{"key":"e_1_2_1_39_1","first-page":"2787","volume-title":"Radiology of the Skull and Brain: Anatomy and Pathology","author":"Kier EL","year":"1977"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.192.1.8208946"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1991.01020102.x"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.05060366.x"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.12010023.x"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.153.3.6387792"},{"key":"e_1_2_1_45_1","first-page":"128","article-title":"Microcephaly and mental retardation","volume":"119","author":"Martin HP","year":"1970","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420160304"},{"key":"e_1_2_1_47_1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1542\/peds.14.5.505","article-title":"The incidence of congenital anomalies. A study of 5,964 pregnancies","volume":"14","author":"McIntosh R","year":"1954","journal-title":"Pediatrics"},{"issue":"5","key":"e_1_2_1_48_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.7863\/jum.1993.12.5.265","article-title":"Nomograms of the fetal lateral ventricles using transvaginal sonography","volume":"12","author":"Monteagudo A","year":"1993","journal-title":"J Ultrasound Med"},{"key":"e_1_2_1_49_1","first-page":"139","volume-title":"Handbook of Clinical Neurology","author":"Myrianthopoulos NC","year":"1977"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199008303230901"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(95)02523-F"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00068-9"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91610-7"},{"issue":"3","key":"e_1_2_1_54_1","first-page":"436","article-title":"Enlarged cisterna magna and the Dandy\u2010Walker malformation: factors associated with chromosome abnormalities","volume":"71","author":"Nyberg DA","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1159\/000120660"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.194.3.7862967"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90075-X"},{"issue":"2","key":"e_1_2_1_58_1","first-page":"250","article-title":"Sonographic evaluation of the normal developmental anatomy of the fetal cerebral ventricles. II. The atria","volume":"73","author":"Pilu GL","year":"1989","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1992.02020088.x"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1992.02030151.x"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1993.03050318.x"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1994.04010065.x"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.09040229.x"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.11050357.x"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.14050320.x"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970100104"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970030316"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999330"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1981.55.1.0089"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10060403.x"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970130603"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.08010042.x"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)80008-6"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6661(199607\/08)5:4<182::AID-MFM4>3.0.CO;2-G"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13050360.x"},{"key":"e_1_2_1_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70277-2"},{"issue":"1","key":"e_1_2_1_77_1","first-page":"123","article-title":"The role ofultrasound in evaluation of patients with elevated maternal serum alpha\u2010fetoprotein: a review (Review)","volume":"78","author":"Watson WJ","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb10649.x"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T13:36:31Z","timestamp":1694612191000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":77,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["10.1002\/pd.310"],"URL":"https:\/\/doi.org\/10.1002\/pd.310","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}