{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T17:52:10Z","timestamp":1769017930533,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,6,6]],"date-time":"2002-06-06T00:00:00Z","timestamp":1023321600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Individuals at risk for Huntington disease face difficult decisions regarding their reproductive options. Most do not wish to pass on the gene for Huntington disease to their children, but may not be prepared themselves to undergo presymptomatic testing and learn their genetic status. For these reasons, many at\u2010risk individuals with a family history of HD would choose a method of genetic diagnosis that would assure them that they can have children unaffected with HD without revealing their own genetic status (non\u2010disclosing). We have shown that, with a carefully designed and executed programme of non\u2010disclosing preimplantation genetic testing, one can successfully assist at\u2010risk couples to have their own biological children who are free from Huntington disease, without forcing parents to confront knowledge of their own genetic status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Couples where one partner was at 50% risk for Huntington disease underwent <jats:italic>in vitro fertilization<\/jats:italic> with preimplantation embryo biopsy and molecular analysis for Huntington disease where appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After extensive counselling and informed consent, 10 couples underwent 13 <jats:italic>in vitro fertilization<\/jats:italic> and two frozen embryo transfer cycles in a programme for non\u2010disclosing preimplantation genetic diagnosis for Huntington disease. In 11 cycles, embryos determined to be free of Huntington disease were transferred, resulting in five clinical pregnancies. One set of twins and three singleton pregnancies have delivered. One pregnancy resulted in a first\u2010trimester loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The option of non\u2010disclosing preimplantation genetic diagnosis should be reviewed, along with other relevant medical options, when counselling at\u2010risk Huntington disease families. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.359","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:29:56Z","timestamp":1033907396000},"page":"503-507","source":"Crossref","is-referenced-by-count":33,"title":["Non\u2010disclosing preimplantation genetic diagnosis for Huntington disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Harvey J.","family":"Stern","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary L.","family":"Harton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Sisson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee A.","family":"Fallon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilli P.","family":"Thorsell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Getlinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan H.","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph D.","family":"Schulman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,6,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199612)16:13<1237::AID-PD98>3.0.CO;2-T"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1087"},{"key":"e_1_2_1_4_1","unstructured":"FieldsRA FuggerEF LevinsonG SchulmanJD.1992.Survival ofcryopreserved biopsied zona\u2010free murine blastocysts.48thAnnual Meeting of the American Fertility Society program supplement;S41."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/306234a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/2.9.713"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90542-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novelgene containing a trinucleotide repeat that is unstable andexpanded on Huntington's disease chromosomes","volume":"72","author":"Huntington's Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.9.1519"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137846"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.6.637"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1996.tb04327.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0015-0282(16)57737-1","article-title":"Intracytoplasmic sperm injection facilitates pregnancy even in the most severe forms of male infertility: pregnancy outcome correlates with maternal age and number of available eggs","volume":"64","author":"Sherins RJ","year":"1995","journal-title":"Fertil Steril"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1981.tb00701.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199812)18:13<1389::AID-PD498>3.0.CO;2-6"},{"key":"e_1_2_1_16_1","first-page":"119","volume-title":"Genetic Counselling:Psychological Dimensions","author":"Wexler NS","year":"1979"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.359","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T22:13:09Z","timestamp":1695679989000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1002\/pd.359"],"URL":"https:\/\/doi.org\/10.1002\/pd.359","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}