{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:12:37Z","timestamp":1791195157203,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T00:00:00Z","timestamp":1332115200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Corpus callosum agenesis (CCA) is generally diagnosed <jats:italic>in utero<\/jats:italic>. Outcome appears to be better if the malformation is isolated. The aim of this study, which is the first one with a long (10 years) and standardized follow up, was to report cognitive abilities of children with isolated CCA diagnosed prenatally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively evaluated 17 children. Clinical examinations, neuropsychological tests were performed each year. School achievement and personal and familial data were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve children completed the entire follow up. One child was finally considered to have associated CCA, because signs of fetal alcohol syndrome had become obvious. Of the 11 other children, three (27%) had borderline intelligence whereas the intelligence levels of eight (73%) were in the normal range, although half of these children experienced some difficulties in scholastic achievement. Neither epilepsy nor intellectual deficiency was noted and intellectual quotient scores correlated strongly with the mother's education level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although prenatal diagnosis of isolated CCA is reliable, false postnatal diagnoses remain possible (10\u201320%) even with complete prenatal screening. Outcome is mostly favorable because intelligence is within the normal range for nearly 3\/4 of the children. However, they frequently have mild learning difficulties. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.3824","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T11:00:04Z","timestamp":1332154804000},"page":"277-283","source":"Crossref","is-referenced-by-count":89,"title":["Isolated corpus callosum agenesis: a ten\u2010year follow\u2010up after prenatal diagnosis (How are the children without corpus callosum at 10\u2009years of age?)"],"prefix":"10.1002","volume":"32","author":[{"given":"Marie\u2010Laure","family":"Moutard","sequence":"first","affiliation":[{"name":"Service de Neurop\u00e9diatrie, Pathologie du d\u00e9veloppement H\u00f4pital Trousseau  26 avenue du Dr Arnold Netter 75571 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Kieffer","sequence":"additional","affiliation":[{"name":"Centre de Suivi et d'Insertion H\u00f4pitaux de Saint\u2010Maurice  14 rue 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