{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:59:42Z","timestamp":1791237582492,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T00:00:00Z","timestamp":1334534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the placental volume and three dimensional (3D) power Doppler vascularization in type I diabetic pregnancies during the first trimester<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>3D\u2010power Doppler ultrasonography of the placenta was performed at 11\u2009+\u20090\u201313\u2009+\u20096\u2009weeks in 32 pregnancies complicated by type I diabetes. Placental volume, vascularization index (VI), flow index (FI), and vascularization flow index (VFI) were calculated using a standardized setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In nine pregnancies, a poor first trimester glycemic control was present as expressed by HbA1c levels\u2009\u2265\u20097%, whereas in the remaining 23 mothers, the HbA1c concentrations were &lt;7%. No differences were found in the placental volumes of diabetic mothers when compared with reference limits. 3D Doppler placental vascular indices were significantly higher in diabetic mothers (VI delta value 0.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0012; FI delta value 0.64,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0008; VFI delta value 1.28,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0039) when compared with reference limits. Pregnancies with HbA1c \u22657% exhibited higher placental vascular indices when compared with diabetic mothers with better glycemic control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In type I diabetic mothers, placental vascular indices are increased and these modifications are more evident in pregnancies with poor first trimester glycemic control. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.3848","type":"journal-article","created":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T05:26:25Z","timestamp":1334553985000},"page":"480-484","source":"Crossref","is-referenced-by-count":32,"title":["First trimester placental volume and three dimensional power doppler ultrasonography in type I diabetic pregnancies"],"prefix":"10.1002","volume":"32","author":[{"given":"Giuseppe","family":"Rizzo","sequence":"first","affiliation":[{"name":"Fetal Medicine Center Genoma  Rome Italy"},{"name":"Dept Obstetrics and Gynecology Universit\u00e0 di Roma \u2018Tor Vergata\u2019  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Capponi","sequence":"additional","affiliation":[{"name":"Dept Obstetrics and Gynecology  Ospedale G.B. Grassi Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"Pietrolucci","sequence":"additional","affiliation":[{"name":"Dept Obstetrics and Gynecology Universit\u00e0 di Roma \u2018Tor Vergata\u2019  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloisa","family":"Aiello","sequence":"additional","affiliation":[{"name":"Dept Obstetrics and Gynecology Universit\u00e0 di Roma \u2018Tor Vergata\u2019  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Arduini","sequence":"additional","affiliation":[{"name":"Dept Obstetrics and Gynecology Universit\u00e0 di Roma \u2018Tor Vergata\u2019  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7103.275"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2010.24"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0739"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.07.021"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2004.043"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050601158206"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-007-0453-y"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.11.010"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4092"},{"key":"e_1_2_5_11_1","first-page":"139","volume":"14","author":"Pairleitner H","year":"1999","journal-title":"Three\u2010dimensional power Doppler sonography: Imaging and quantifying blood flow and vascularization. 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