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We consider the risk of harm to a woman or her fetus following the detection of a copy number variant of uncertain significance, whether it is ethically justifiable to withhold any test result information from a woman, what constitutes an \u2018informed choice\u2019 when women are offered CMA in pregnancy and whether clinicians are morally responsible for \u2018unnecessary\u2019 termination of pregnancy. Although we are cognisant of the distress associated with uncertain prenatal results, we argue in favour of the autonomy of women and their right to information from genome\u2010wide CMA in order to make informed choices about their pregnancies. We propose that information material to a woman's decision\u2010making process, including uncertain information, should not be withheld, and that it would be paternalistic for clinicians to try to take responsibility for women's decisions to terminate pregnancies. Non\u2010directive pre\u2010test and post\u2010test genetic counselling is central to the delivery of these ethical objectives. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.3849","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T10:37:54Z","timestamp":1333449474000},"page":"389-395","source":"Crossref","is-referenced-by-count":83,"title":["Genetic counselling and ethical issues with chromosome microarray analysis in prenatal testing"],"prefix":"10.1002","volume":"32","author":[{"given":"George","family":"McGillivray","sequence":"first","affiliation":[{"name":"Royal Women's Hospital  Melbourne Victoria Australia"},{"name":"Victorian Clinical Genetics Services Royal Children's Hospital  Melbourne Victoria Australia"},{"name":"Murdoch Children's Research Institute Royal Children's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill A","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Signature Genomic Laboratories PerkinElmer, Inc.  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