{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:09:04Z","timestamp":1775732944543,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,6,6]],"date-time":"2002-06-06T00:00:00Z","timestamp":1023321600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to assess whether preimplantation genetic diagnosis (PGD) was an acceptable alternative to prenatal diagnosis in couples at risk of giving birth to a child with \u03b1\u2010 or \u03b2\u2010thalassaemia in an Asian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An information leaflet was distributed to the women at risk. They were asked to complete a questionnaire after having an interview with a designated investigator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 141 valid questionnaires were analysed; 82.3% of the women considered PGD either the same or better than conventional prenatal diagnosis. Women with an affected child or a subfertility problem were more willing to accept PGD and to undergo this procedure in their future pregnancies. Their main concern about PGD was damage to the embryo during the PGD procedure. The most important perceived advantage of PGD was avoidance of termination of an affected pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PGD is an acceptable alternative to conventional prenatal diagnosis in women at risk of giving birth to a child with \u03b1\u2010 or \u03b2\u2010thalassaemia in an Asian population. This is particularly true in women with a subfertility problem and in women who already have an affected child. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.387","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:29:56Z","timestamp":1033907396000},"page":"508-511","source":"Crossref","is-referenced-by-count":41,"title":["Attitude of at\u2010risk subjects towards preimplantation genetic diagnosis of \u03b1\u2010 and \u03b2\u2010thalassaemias in Hong Kong"],"prefix":"10.1002","volume":"22","author":[{"given":"Pui","family":"Wah Hui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung Hang","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Hoi Yin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Shu Biu","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest Hung Yu","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pak Chung","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,6,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.7.1936"},{"key":"e_1_2_1_3_1","first-page":"490","article-title":"Alpha and beta thalassemias in Hong Kong","volume":"110","author":"Chan V","year":"1997","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_1_4_1","first-page":"203","article-title":"Preimplantation diagnosis of alpha\u2010thalassaemia by blastomere aspiration and polymerase chain reaction: preliminary experience","volume":"95","author":"Chang MY","year":"1996","journal-title":"J Formos Med Assoc"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.12.2673"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.1.233"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/344768a0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199912)19:13<1217::AID-PD723>3.0.CO;2-2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022571822585"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138002"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.1.1999.8.521"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138508"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970110803"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.2.341"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02065946"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09874.x"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.107439"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022536005746"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.387","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T22:12:50Z","timestamp":1695679970000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1002\/pd.387"],"URL":"https:\/\/doi.org\/10.1002\/pd.387","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}