{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:50:03Z","timestamp":1767833403913,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T00:00:00Z","timestamp":1336089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the study was to evaluate a biochemical analysis of fluid sampled <jats:italic>in utero<\/jats:italic> from fetal abdominal cystic masses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study of 42 intra\u2010abdominal cystic masses [ovarian cysts (<jats:italic>n<\/jats:italic>\u2009=\u200922), cloaca (<jats:italic>n<\/jats:italic>\u2009=\u20098), urodigestive fistulae (<jats:italic>n<\/jats:italic>\u2009=\u20094), and urogenital sinuses (<jats:italic>n<\/jats:italic>\u2009=\u20098)] was carried out. The control group (<jats:italic>n<\/jats:italic>\u2009=\u200930) consisted of fetal urine. Seven biochemical markers were assayed: sodium, estradiol, \u03b2<jats:sub>2<\/jats:sub>\u2010microglobulin, total proteins and digestive enzymes, gamma\u2010glutamyl transpeptidase, aminopeptidase M, and intestinal alkaline phosphatase isoenzyme. Outcome of pregnancies and final diagnosis of intra\u2010abdominal mass were known in all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Biochemical patterns allowed to demonstrate (1) an ovarian origin based on elevated level of estradiol and of total proteins (100% specificity, 100% sensitivity); (2) urodigestive fistula based on the presence of high levels of digestive enzymes (cloaca in female fetuses or recto\u2010urethral fistula in male fetuses); and (3) a renal origin (urinary pattern with low total proteins and absence of digestive enzymes); however, a biochemical pattern could not differentiate between fetal urogenital sinus and megacystis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Etiological diagnosis of a fetal cystic abdominal mass could impact both prenatal and postnatal management providing adapted prenatal counseling by a pediatric surgeon in surgically correctable congenital anomalies. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.3871","type":"journal-article","created":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T12:57:24Z","timestamp":1336136244000},"page":"627-631","source":"Crossref","is-referenced-by-count":13,"title":["Biochemical analysis of cystic fluid in the diagnosis of fetal intra\u2010abdominal masses"],"prefix":"10.1002","volume":"32","author":[{"given":"Edouard","family":"Lecarpentier","sequence":"first","affiliation":[{"name":"Gyn\u00e9cologie Obst\u00e9trique H\u00f4pital Robert Debr\u00e9, AP\u2010HP, Universit\u00e9 Paris\u2010Diderot  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Dreux","sequence":"additional","affiliation":[{"name":"Biochimie\u2010Hormonologie H\u00f4pital Robert Debr\u00e9, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Blanc","sequence":"additional","affiliation":[{"name":"Chirurgie 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