{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:00:13Z","timestamp":1791237613745,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T00:00:00Z","timestamp":1336089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify pathological placental differences between early\u2010onset and late\u2010onset preeclampsia, in relation to fetal growth restriction (FGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Placentas from patients with preeclampsia were analyzed for lesions of maternal vascular supply consistent with maternal underperfusion and lesions of fetal vascular supply consistent with fetal thrombo\u2010occlusive disease. Findings were compared between patients who gave birth before 34\u2009weeks (early\u2010onset preeclampsia) and after 34\u2009weeks (late\u2010onset preeclampsia).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the late\u2010onset group (<jats:italic>n<\/jats:italic>\u2009=\u200993), the early\u2010onset group (<jats:italic>n<\/jats:italic>\u2009=\u200937) had higher rates of FGR (62.2% vs 25.8%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and lesions of maternal vascular supply (95% vs 60%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Within the early\u2010onset group, cases with FGR (<jats:italic>n<\/jats:italic>\u2009=\u200923) had more lesions of fetal vascular supply (47.8% vs 7%, <jats:italic>P<\/jats:italic>\u2009=\u20090.01), with similar high rates of lesions of maternal vascular supply (91% vs 100%) compared with those without FGR. Within the late\u2010onset preeclampsia group, cases with FGR (<jats:italic>n<\/jats:italic>\u2009=\u200924) had higher rates of maternal vascular supply lesions (88% vs 51%, <jats:italic>P<\/jats:italic>\u2009=\u20090.003) than those without FGR, but similar rates of fetal vascular supply lesions (25% vs 16%, <jats:italic>P<\/jats:italic>\u2009=\u20090.32).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The placental fetal vascular supply lesions in combination with maternal vascular lesions are more dominant in early\u2010onset preeclampsia with FGR as compared with early\u2010onset preeclampsia without FGR. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.3872","type":"journal-article","created":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T13:01:50Z","timestamp":1336136510000},"page":"632-637","source":"Crossref","is-referenced-by-count":82,"title":["The placental component in early\u2010onset and late\u2010onset 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