{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:46:34Z","timestamp":1778683594177,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T00:00:00Z","timestamp":1335916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficiency of first\u2010trimester fetal growth restriction (FGR), low pregnancy\u2010associated plasma protein A (PAPP\u2010A), and their combination for predicting small for gestational age (SGA) at delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study of women undergoing first\u2010trimester aneuploidy screening. Fetal crown\u2013rump lengths (CRLs) were at 10 to 14\u2009weeks\u2019 gestation and converted to gestational age adjusted <jats:italic>Z<\/jats:italic>\u2010scores. Low PAPP\u2010A was defined as levels\u2009&lt;\u20095th percentile for GA. Receiver\u2010operating characteristic curves were used to assess screening efficiencies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 3269 pregnancies meeting the inclusion criteria 185 (5.7%) infants were SGA. CRL <jats:italic>Z<\/jats:italic>\u2010score\u2009&lt;\u2009\u22121.0 standard deviation was identified as the optimal definition of early FGR. Using either CRL <jats:italic>Z<\/jats:italic>\u2010score\u2009&lt;\u2009\u22121.0 standard deviation or PAPP\u2010A\u2009&lt;\u20095th percentile had the highest sensitivity (33%) with a specificity of 82.1% when screening for SGA. Using a combination resulted in an increased association (adjusted odds ratio 4.23[confidence interval 1.37\u201313.03]) at the expense of significantly reduced sensitivity (3.13%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>First\u2010trimester FGR and PAPP\u2010A\u2009&lt;\u20095th percentile are associated with delivery of an SGA infant. Neither of these parameters or the combination of the two are sufficient powerful predictors of SGA to be clinically useful screening tools. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.3891","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T02:01:35Z","timestamp":1336010495000},"page":"724-729","source":"Crossref","is-referenced-by-count":27,"title":["Efficiency of first\u2010trimester growth restriction and low pregnancy\u2010associated plasma protein\u2010A in predicting small for gestational age at delivery"],"prefix":"10.1002","volume":"32","author":[{"given":"Jeanine F.","family":"Carbone","sequence":"first","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine and Ultrasound Department of Obstetrics and Gynecology Washington University in St. Louis  St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Methodius G.","family":"Tuuli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Bradshaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Liebsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony O.","family":"Odibo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.18.2249"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812173392504"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39129.637917.AE"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.78"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(67)80066-0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.1998.770611.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03009.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/417916a"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200006000-00001"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.4.8430"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.052"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.05.068"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8808"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5206"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2487"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00386-X"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2397"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2671"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.07.016"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2578"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0913"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.06.035"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2009.28.12.1639"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2006.25.8.973"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.3891","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.3891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.3891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T19:51:20Z","timestamp":1697485880000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.3891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,2]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1002\/pd.3891"],"URL":"https:\/\/doi.org\/10.1002\/pd.3891","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,2]]}}}