{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:13:59Z","timestamp":1754194439912},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T00:00:00Z","timestamp":1337126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Complications in pregnancy are suggested to be the result of intrauterine conditions in the first trimester of pregnancy. Three\u2010dimensional ultrasound volume measurements might give more information, compared with two\u2010dimensional measurements. Commonly available methods for volume measurements are not suited for daily practice. This is a report of preliminary results of a promising, more practical semi\u2010automated method for volume calculations with three\u2010dimensional ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Volume datasets of 16 objects (10.2\u201341.5\u2009cm<jats:sup>3<\/jats:sup>) were obtained. Euclidean shortening flow and Perona and Malik were used as image enhancement techniques. The image gradient was calculated. The points of interest were detected by the iso\u2010intensity and the edge\u2010detection technique. Volume measurements with Volume Computer\u2010aided AnaLysis (VOCAL) are used as a reference. A volume dataset of a first trimester fetus was acquired to test this method <jats:italic>in vivo<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mathematical calculations with iso\u2010intensity (Perona and Malik: average\u2009=\u2009\u22121.57\u2009cm<jats:sup>3<\/jats:sup>, SD\u2009=\u20094.05; and Euclidean shortening flow: average\u2009=\u2009\u22121.38\u2009cm<jats:sup>3<\/jats:sup>, SD\u2009=\u20092.47) showed results comparable with the VOCAL method (average\u2009=\u2009+1.28\u2009cm<jats:sup>3<\/jats:sup>, SD\u2009=\u20092.07). We also succeeded in detecting all voxels in the whole contour of a 12\u2010week fetus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mathematical volume calculations are possible with the semi\u2010automated method. We were able to apply this new method on a first trimester fetus. This new method is promising for future use in the daily practice. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.3900","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T13:43:23Z","timestamp":1337262203000},"page":"770-776","source":"Crossref","is-referenced-by-count":4,"title":["A new semi\u2010automated method for fetal volume measurements with three\u2010dimensional ultrasound: preliminary results"],"prefix":"10.1002","volume":"32","author":[{"given":"Nicol A. 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