{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:02:00Z","timestamp":1774526520831,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T00:00:00Z","timestamp":1339545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To present the current status of the prenatal diagnosis services and results from the largest thalassaemia center in Egypt treating 3000 patients. Traditionally, prenatal diagnosis has not been successful in reducing the births of affected children in Egypt, because the majority of women undergoing prenatal diagnosis continued to have affected pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010one pregnant mothers at risk for \u03b2\u2010thalassaemia underwent prenatal diagnosis by chorionic villus sampling (<jats:italic>n<\/jats:italic>\u2009=\u200957) or amniocentesis (<jats:italic>n<\/jats:italic>\u2009=\u200914) between 11 to 14 weeks of gestation. Molecular characterization of fetal DNA by reverse dot blot hybridization and polymerase chain reaction\u2010amplification refractory mutation system techniques was conducted in all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four women (33.8%) were found to have affected fetuses; 100% of these women opted to terminate the pregnancy. The change in attitude towards termination of pregnancy was related to in\u2010depth counseling of the religious aspects towards prenatal diagnosis and termination of pregnancy. Forty\u2010eight women (66.2%) with normal or carrier fetuses for \u03b2\u2010thal requested human leukocyte antigen typing of the fetal material to determine if the fetus was a human leukocyte antigen match for their existing thalassaemic siblings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that prenatal diagnosis is feasible and acceptable in Egypt, a Muslim country, provided an in\u2010depth discussion, which also addresses the religious considerations of prevention, is held with the couples. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.3901","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T09:59:01Z","timestamp":1339581541000},"page":"777-782","source":"Crossref","is-referenced-by-count":25,"title":["Prenatal diagnosis for thalassaemia in Egypt: what changed parents' attitude?"],"prefix":"10.1002","volume":"32","author":[{"given":"A.","family":"El\u2010Beshlawy","sequence":"first","affiliation":[{"name":"Pediatric Hematology Department Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"El\u2010Shekha","sequence":"additional","affiliation":[{"name":"Fetal Medicine Department Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Momtaz","sequence":"additional","affiliation":[{"name":"Fetal Medicine Department Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Said","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Department Cairo University  Cairo 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