{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:32:57Z","timestamp":1789903977603,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T00:00:00Z","timestamp":1339977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether spontaneous preterm delivery can be predicted from the amount of cell free fetal DNA (cffDNA) as determined by routine fetal <jats:italic>RHD<\/jats:italic> genotyping at 25\u2009weeks\u2019 gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Cohort study including RhD negative women participating in a routine <jats:italic>RHD<\/jats:italic> screening programme. A standard dilution curve was used to quantify the amounts of cffDNA. Values above the 95<jats:sup>th<\/jats:sup> centile for the study population defined high levels of cffDNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a highly significant association between preterm delivery and cffDNA levels above the 95<jats:sup>th<\/jats:sup> centile (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). Using logistic regression, women with high levels of cffDNA had an odds ratio of 6.3 (95% confidence interval: 1.9\u201320.9) for preterm delivery before 37 weeks and an odds ratio for delivery before 34\u2009weeks of 16.6 (95% confidence interval: 3.2\u201384.7) when adjusting for gestational age at sampling, body mass index and previous miscarriages\/terminations of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High levels of cffDNA at 25\u2009weeks are associated with increased risk of spontaneous preterm delivery. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.3917","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T18:12:33Z","timestamp":1340043153000},"page":"840-845","source":"Crossref","is-referenced-by-count":66,"title":["High levels of fetal DNA are associated with increased risk of spontaneous preterm delivery"],"prefix":"10.1002","volume":"32","author":[{"given":"Tanja R.","family":"Jakobsen","sequence":"first","affiliation":[{"name":"Department of Fetal Medicine 4002, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik B.","family":"Clausen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology  2034 Rigshospitalet Copenhagen University Hospital Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Rode","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine 4002, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten H.","family":"Dziegiel","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology  2034 Rigshospitalet Copenhagen University Hospital Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Tabor","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine 4002, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Faculty of Health Science Copenhagen University  Copenhagen 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