{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:00:16Z","timestamp":1762866016472},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T00:00:00Z","timestamp":1339545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Beyond the classic triad of peripheral precocious puberty, <jats:italic>caf\u00e9\u2010au\u2010lait<\/jats:italic> skin pigmentation and polyostotic fibrous dysplasia, partial presentation McCune\u2013Albright syndrome (MAS) has been reported, including the association of isolated recurrent ovarian cysts in early infancy. The aims of this study were to determine whether isolated voluminous fetal unilateral ovarian cysts (diameter\u2009&gt;\u20094\u2009cm) may be associated with a Gs\u03b1 activating mutation, suggestive of MAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We followed five female fetuses presenting with voluminous unilateral ovarian cysts by ultrasonography until delivery. At birth, all patients underwent percutaneous cyst aspiration and two patients later underwent ovariectomy. A sensitive PCR\u2010based method was used to analyze the Gs\u03b1 activating mutation in DNA obtained from ovarian cystic fluids or tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the five cases, one Gs\u03b1 mutation (R201C) was identified in the ovarian tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We demonstrate for the first time that voluminous fetal unilateral ovarian cysts may be suggestive of MAS. Systematic search for the Gs\u03b1 mutation should be performed in all newborns with voluminous fetal unilateral ovarian cysts requiring percutaneous cyst aspiration, because early diagnosis of MAS prevents unnecessary oophorectomy to eliminate questions of malignancy and imposes long\u2010term clinical, biological, and imaging follow\u2010up to detect other early manifestations of MAS. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.3921","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T10:08:42Z","timestamp":1339582122000},"page":"859-863","source":"Crossref","is-referenced-by-count":10,"title":["Fetal ovarian cysts: an early manifestation of McCune\u2013Albright syndrome?"],"prefix":"10.1002","volume":"32","author":[{"given":"Laura","family":"Gaspari","sequence":"first","affiliation":[{"name":"Unit\u00e9 d'Endocrinologie\u2010Gyn\u00e9cologie P\u00e9diatriques, Service de P\u00e9diatrie, H\u00f4pital Arnaud\u2010de\u2010Villeneuve CHU Montpellier et Universit\u00e9 Montpellier 1  Montpellier France"},{"name":"Service d'Hormonologie (D\u00e9veloppement et Reproduction), H\u00f4pital Lapeyronie CHU Montpellier et Universit\u00e9 Montpellier 1  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Paris","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Endocrinologie\u2010Gyn\u00e9cologie P\u00e9diatriques, Service de P\u00e9diatrie, H\u00f4pital Arnaud\u2010de\u2010Villeneuve CHU Montpellier et Universit\u00e9 Montpellier 1  Montpellier France"},{"name":"Service d'Hormonologie (D\u00e9veloppement et Reproduction), H\u00f4pital Lapeyronie CHU Montpellier et Universit\u00e9 Montpellier 1  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Nicolino","sequence":"additional","affiliation":[{"name":"H\u00f4pital Femme\u2010M\u00e8re\u2010Enfant Service d'Endocrinology P\u00e9diatrique  CHU de Lyon Lyon France"},{"name":"INSERM U870 Centre d'Investigation Clinique  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Hameury","sequence":"additional","affiliation":[{"name":"H\u00f4pital Femme\u2010M\u00e8re\u2010Enfant, Service de Chirurgie P\u00e9diatrique Infantile CHU de Lyon University  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Bonnaure","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Endocrinologie\u2010Gyn\u00e9cologie P\u00e9diatriques, Service de P\u00e9diatrie, H\u00f4pital Arnaud\u2010de\u2010Villeneuve CHU Montpellier et Universit\u00e9 Montpellier 1  Montpellier France"},{"name":"Service d'Hormonologie (D\u00e9veloppement et Reproduction), H\u00f4pital Lapeyronie CHU Montpellier et Universit\u00e9 Montpellier 1  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Pienkowski","sequence":"additional","affiliation":[{"name":"H\u00f4pital des Enfants, Service d'Endocrinologie P\u00e9diatrique CHU de Toulouse  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nad\u00e8ge","family":"Servant","sequence":"additional","affiliation":[{"name":"Service d'Hormonologie (D\u00e9veloppement et Reproduction), H\u00f4pital Lapeyronie CHU Montpellier et Universit\u00e9 Montpellier 1  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Kalfa","sequence":"additional","affiliation":[{"name":"Service d'Hormonologie (D\u00e9veloppement et Reproduction), H\u00f4pital Lapeyronie CHU Montpellier et Universit\u00e9 Montpellier 1  Montpellier France"},{"name":"Service de Chirurgie P\u00e9diatrique, H\u00f4pital Lapeyronie CHU Montpellier et Universit\u00e9 Montpellier 1  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Sultan","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Endocrinologie\u2010Gyn\u00e9cologie P\u00e9diatriques, Service de P\u00e9diatrie, H\u00f4pital Arnaud\u2010de\u2010Villeneuve CHU Montpellier et Universit\u00e9 Montpellier 1  Montpellier France"},{"name":"Service d'Hormonologie (D\u00e9veloppement et Reproduction), H\u00f4pital Lapeyronie CHU Montpellier et Universit\u00e9 Montpellier 1  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM193704292161701"},{"key":"e_1_2_7_3_1","first-page":"743","article-title":"Osteitis fibrosa cystica. 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