{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:18:41Z","timestamp":1789996721530,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T00:00:00Z","timestamp":1341273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim is to describe the performance of first\u2010trimester combined risk assessment in twin pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Maternal serum free beta\u2010human chorionic gonadotrophin and pregnancy\u2010associated plasma protein A (PAPP\u2010A) were determined at 8 to 12\u2009weeks and fetal nuchal translucency (NT) was measured at 11 to 13+6\u2009weeks. The individual risk was estimated for each fetus using the combined test in dichorionic twins. In monochorionic twins, the mean risk assessment of the two fetuses was used. An invasive diagnostic procedure was offered when the risk was \u22651\u2009:\u2009270 in either one of the fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From February 2007 to June 2011, 447 twin pregnancies were enrolled in this study. There were 402 (89.9%) dichorionic and 45 (10.1%) monochorionic twins. In dichorionic twins, mean crown\u2013rump length (CRL) was 63.9\u2009mm; median NT multiples of the median (MoM) was 0.97; median \u0392\u2010hCG was MoM 1.74; median PAPP\u2010A was 1.72. In monochorionic twins, mean CRL was 61.9\u2009mm; median NT MoM was 0. 98; median \u0392\u2010hCG MoM was 1.44; and median PAPP\u2010A was 1.51. Two pregnancies with Down syndrome were detected by first trimester screening, both in dichorionic twins. The false positive rate was 5.7% (95% confidence interval 4.1\u20137.3) and 4.4% (95% confidence interval 0.1\u20138.8%) in dichorionic and monochorionic twins, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combined test in twins appears to be a good method for Down syndrome screening with a high detection rate and an acceptable false\u2010positive rate. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.3934","type":"journal-article","created":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T07:51:17Z","timestamp":1341301877000},"page":"927-932","source":"Crossref","is-referenced-by-count":16,"title":["First trimester risk assessment for trisomy 21 in twin pregnancies combining nuchal translucency and first trimester biochemical markers"],"prefix":"10.1002","volume":"32","author":[{"given":"Pilar","family":"Prats","sequence":"first","affiliation":[{"name":"Fetal Medicine Service, Department of Obstetrics, Gynecology and Reproductive Medicine Institut Universitari Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Fetal Medicine Service, Department of Obstetrics, Gynecology and Reproductive Medicine Institut Universitari Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmina","family":"Comas","sequence":"additional","affiliation":[{"name":"Fetal Medicine Service, Department of Obstetrics, Gynecology and Reproductive Medicine Institut Universitari Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bienvenido","family":"Puerto","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine, Institut Clinic de Ginecologia, Obstetr\u00edcia I Neonatologia Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199601)16:1<29::AID-PD801>3.0.CO;2-K"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(96)00424-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1375\/136905203322296566"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2006.01.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09550.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-5013(08)73319-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.06.037"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1304"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02222.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.390"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb11946.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07060421.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200002)20:2<91::AID-PD759>3.0.CO;2-X"},{"key":"e_1_2_6_15_1","first-page":"1037","article-title":"Calculated risk of chromosomal abnormalities in twin gestations","volume":"76","author":"Rodis JF","year":"1990","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_16_1","unstructured":"Fergurson SmithM ArbuzovaS BennP CanickJ CuckleH FortunyA et al.A position statement from the scientific committee of the Intenational Down Syndrome Screening Group. 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