{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T23:08:22Z","timestamp":1777158502712,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,8,18]],"date-time":"2012-08-18T00:00:00Z","timestamp":1345248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study's aim was to evaluate the effect of preeclampsia and intrauterine growth restriction (IUGR) on fetal cardiac function, and the relationship of the latter with adverse pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We did a cross\u2010sectional study of 132 women with uncomplicated singleton pregnancies, 34 with preeclampsia without IUGR, and 12 with preeclampsia and IUGR. Fetal cardiac structure and function were evaluated using fetal two\u2010dimension ultrasound, pulsed wave Doppler and tissue Doppler imaging (TDI). Data were analyzed by <jats:italic>t<\/jats:italic>\u2010tests, ANOVA, Chi\u2010square tests, or Wilcoxon rank\u2010sum test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the normal pregnancy group, mitral\/tricuspid early systolic peak velocity of annulus\/late diastolic peak velocity of annulus (Sa) and left ventricular (LV)\/right ventricular (RV)\u2009early diastolic peak velocity at the annulus (Ea) in TDI decreased in preeclampsia with or without IUGR (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). LV\/RV\u2009Ea underwent a gestational decrease in preeclampsia with or without IUGR (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The changes in mitral\/tricuspid Sa and LV\u2009Sa associated with preeclampsia were even more pronounced with preterm delivery at less than 34 gestational weeks and stillbirth (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intrauterine growth restriction influences fetal cardiac function in the presence of preeclampsia, and TDI may be a sensitive and preferable method to detect such changes. Fetal LV\/RV\u2009Ea is a potential marker for early fetal cardiac diastolic impairment, and mitral\/tricuspid Sa and LV\u2009Sa may be predictors for adverse pregnancy outcomes. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.3948","type":"journal-article","created":{"date-parts":[[2012,8,18]],"date-time":"2012-08-18T07:21:07Z","timestamp":1345274467000},"page":"1021-1028","source":"Crossref","is-referenced-by-count":14,"title":["Fetal tissue Doppler imaging in pregnancies complicated with preeclampsia with or without intrauterine growth restriction"],"prefix":"10.1002","volume":"32","author":[{"given":"Qiongjie","family":"Zhou","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunyun","family":"Ren","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital Fudan University  Shanghai 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