{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:24:29Z","timestamp":1780701869190,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,8,18]],"date-time":"2012-08-18T00:00:00Z","timestamp":1345248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study pregnancy outcomes and fetal renal prognosis markers in cases of exposure to renin\u2013angiotensin system blockers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study of a series of 21 patients exposed to blockers of the renin\u2013angiotensin system during pregnancy. Two markers were prenatally studied, fetal serum \u03b22\u2010microglobulin and amniotic fluid volume. Poor renal prognosis evaluation was based on postnatal glomerular filtration rate or on the presence of renal histologic lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 21 fetuses, only one had a normal postnatal renal function at birth (oligohydramnios regression and normal \u03b22\u2010microglobulin). All fetuses with persistent oligohydramnios or \u03b22\u2010microglobulin \u22655\u2009mg\/L presented an adverse renal outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Exposure to renin\u2013angiotensin system blockers complicated by oligohydramnios is associated with a very poor outcome. We propose a prenatal management based on amniotic fluid volume monitoring and fetal serum \u03b22\u2010microglobulin. However, our preliminary results have to be confirmed by a larger study. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.3960","type":"journal-article","created":{"date-parts":[[2012,8,18]],"date-time":"2012-08-18T07:07:21Z","timestamp":1345273641000},"page":"1071-1076","source":"Crossref","is-referenced-by-count":31,"title":["Prognosis and outcome of pregnancies exposed to renin\u2013angiotensin system blockers"],"prefix":"10.1002","volume":"32","author":[{"given":"Emmanuel","family":"Spaggiari","sequence":"first","affiliation":[{"name":"Developmental Biology AP\u2010HP, Robert Debr\u00e9 Hospital  Paris France"},{"name":"University Paris 7 Diderot, Paris Sorbonne Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Heidet","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales H\u00e9r\u00e9ditaires de l'Enfant et de l'Adulte, Pediatric Nephrology 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