{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:50:52Z","timestamp":1756572652880},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,16]],"date-time":"2012-09-16T00:00:00Z","timestamp":1347753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the prevalence of consanguineous patients at a Western European prenatal genetic counseling clinic and to describe demographic as well as health\u2010related characteristics of this patient group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Retrospective analysis of 1964 primary consultations at the Prenatal Genetic Counseling Outpatient Clinic at the Medical University of Vienna General Hospital in Austria. Characteristics of consanguineous patients were compared with those of a control group of not\u2010related unions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 8.9% (174\/1964) of all patients lived in a consanguineous union, meaning they were related as second cousin or closer [78.7% (137\/174) first cousin, 14.4% (25\/174) second cousin, 6.3% (11\/174) first cousin once removed or 0.6% (1\/174) uncle\/niece]. Consanguineous patients were significantly younger (26.6\u2009\u00b1\u20095.4 vs 30.4\u2009\u00b1\u20096.5, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and of non\u2010Austrian background [92.5% (161\/174) vs 32.8% (57\/174), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01] than not\u2010related controls. Forty\u2010six per cent (80\/174) were referred during an ongoing pregnancy. The main counseling issue was family history of consanguinity (ICD Z84.3) in 31.6% (55\/174) of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Estimations of the prevalence of consanguinity among the general population in Western Europe likely highly underestimate the evaluated prevalence among patients referred for prenatal genetic counseling. Counseling strategies need to take into consideration that consanguineous patients are more likely to be young and have an immigrant background. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.3971","type":"journal-article","created":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T03:13:11Z","timestamp":1347851591000},"page":"1133-1138","source":"Crossref","is-referenced-by-count":12,"title":["Prenatal genetic counseling and consanguinity"],"prefix":"10.1002","volume":"32","author":[{"given":"Angela","family":"Posch","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Feto\u2010maternal Medicine Medical University of Vienna  Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Springer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Feto\u2010maternal Medicine Medical University of Vienna  Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Langer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Feto\u2010maternal Medicine Medical University of Vienna  Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wibke","family":"Blaicher","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Feto\u2010maternal Medicine Medical University of Vienna  Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthold","family":"Streubel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Feto\u2010maternal Medicine Medical University of Vienna  Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Feto\u2010maternal Medicine Medical University of Vienna  Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2001.600201.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg754"},{"issue":"1","key":"e_1_2_6_4_1","first-page":"1779","article-title":"Evolution in health and medicine Sackler colloquium: consanguinity, human evolution, and complex diseases","volume":"107","author":"Bittles AH","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e318217477f"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.25.3.186"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201983"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30432"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970211)68:4<472::AID-AJMG20>3.0.CO;2-O"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.44.2.130"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009126"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/20.2.135"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014460310001652211"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-008-9163-2"},{"key":"e_1_2_6_15_1","unstructured":"Statistik Austria.Bevoelkerung mit Migrationshintergrund.2011. 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