{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:21:52Z","timestamp":1781259712054,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T00:00:00Z","timestamp":1349308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the routine midsagittal view of the posterior brain at the 11\u201313\u2009weeks' ultrasound examination, for predicting open neural tube defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Posterior brain was examined midsagittally for normality of the four\u2010line view (upper and lower border of the brain stem, the choroid plexus of the fourth ventricle and the occipital bone). Intracranial translucency and cisterna magna (CM) were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The posterior brain was assessed in 1330 cases. The four\u2010line view was normal in all but one case. In the two cases of open spina bifida contained in the study population, intracranial translucency was within normal range. The CM and the four\u2010line view were normal in the first case, whereas in the second case, the four\u2010line view was abnormal, and CM was obliterated and impossible to measure. No other cases of abnormal four\u2010line view were observed in the study population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Obliteration of the CM appears to be the most consistent early sign of open neural tube defects. Attention should focus on either measuring the cisterna magna or simply observing the presence of four lines in the midsagittal view of the posterior brain. However, these early signs of brain herniation are not present in all abnormal cases. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.3973","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T06:25:06Z","timestamp":1349331906000},"page":"1143-1146","source":"Crossref","is-referenced-by-count":31,"title":["Assessment of the posterior brain at 11\u201314\u2009weeks for the prediction of open neural tube defects"],"prefix":"10.1002","volume":"32","author":[{"given":"Ioannis","family":"Kavalakis","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Rhodos General Hospital  Rhodes Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athena P.","family":"Souka","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, 3rd Department of Obstetrics and Gynecology University of Athens, \u2018Attikon\u2019 University Hospital  Athens Greece"},{"name":"Fetal Medicine Unit Leto Maternity Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Pilalis","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, 3rd Department of Obstetrics and Gynecology University of Athens, \u2018Attikon\u2019 University Hospital  Athens Greece"},{"name":"Fetal Medicine Unit Leto Maternity Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Papastefanou","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, 3rd Department of Obstetrics and Gynecology University of Athens, \u2018Attikon\u2019 University Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Kassanos","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, 3rd Department of Obstetrics and Gynecology University of Athens, \u2018Attikon\u2019 University Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7329"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10128"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2869"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2632"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10118"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8994"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10137"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2011.30.12.1643"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2944"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7718"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10111"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8957"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3920"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338113"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3868"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2832"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.3973","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.3973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T17:22:16Z","timestamp":1698686536000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.3973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,4]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1002\/pd.3973"],"URL":"https:\/\/doi.org\/10.1002\/pd.3973","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,4]]}}}