{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T07:10:39Z","timestamp":1698736239553},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T00:00:00Z","timestamp":1348531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Increased thrombin generation has been implicated as a mechanism for several obstetric syndromes including preterm birth preceded by preterm labor (PTL) and preterm premature rupture of membranes (PPROM). In this study, we attempted to determine whether PTL or PPROM are associated with changes in the maternal plasma thrombin level during the early second trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a case\u2013control study in which maternal thrombin\u2013antithrombin (TAT) III complex concentrations at 15\u201321\u2009weeks were compared between normal controls (<jats:italic>n<\/jats:italic>\u2009=\u200985) and women subsequently delivering preterm, due to either PTL with intact membranes (<jats:italic>n<\/jats:italic>\u2009=\u200921) or PPROM (<jats:italic>n<\/jats:italic>\u2009=\u200920). Statistical analysis was conducted using non\u2010parametric statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PTL patients with intact membranes showed non\u2010significant differences in median plasma TAT level (110.1\u2009\u00b5g\/L) compared with the control group (107.9\u2009\u00b5g\/L). Similarly, women destined to deliver preterm because of PPROM had non\u2010significantly higher plasma TAT level (134.3\u2009\u00b5g\/L) than those in the control group (107.9\u2009\u00b5g\/L) (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Logistic regression analysis demonstrated that after controlling for confounders including vaginal bleeding, TAT levels remained not significantly associated with subsequent spontaneous preterm birth (<jats:italic>p<\/jats:italic>\u2009=\u20090.27).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal plasma TAT level is unsuitable as an early second trimester predictor of preterm birth preceded by PTL or PPROM. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.3978","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T09:32:00Z","timestamp":1348565520000},"page":"1170-1173","source":"Crossref","is-referenced-by-count":0,"title":["Early second trimester maternal plasma levels of thrombin\u2010inhibitor complexes and subsequent spontaneous preterm delivery"],"prefix":"10.1002","volume":"32","author":[{"given":"Da Eun","family":"Lee","sequence":"first","affiliation":[{"name":"Laboratory of Medical Genetics Cheil General Hospital and Women's Healthcare Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Yeon","family":"Park","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics Cheil General Hospital and Women's Healthcare Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June Seek","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics Cheil General Hospital and Women's Healthcare Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hyae","family":"Lim","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics Cheil General Hospital and Women's Healthcare Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hyug","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Mee","family":"Ryu","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics Cheil General Hospital and Women's Healthcare Center  Seoul Korea"},{"name":"Department of Obstetrics and Gynecology Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Centers for Disease Control and Prevention, National Center for Health Statistics. 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