{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:35:26Z","timestamp":1757702126295},"reference-count":44,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Accurate identification of preeclampsia (PE) at triage is essential to reduce maternal and fetal morbidity and mortality. The use of maternal blood based biomarkers may facilitate the clinician's ability to assess high risk pregnancies at triage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cross\u2010sectional study was performed to investigate the value of soluble fms\u2010like tyrosine kinase\u20101 (sFlt\u20101), soluble endoglin (sEng), placental growth factor (PlGF), sP\u2010selectin, cell\u2010free fetal DNA and total cell\u2010free DNA in patients with late\u2010onset PE versus gestational age\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The diagnosis of late\u2010onset PE (<jats:italic>n<\/jats:italic>\u2009=\u200921) at triage was significantly improved by altered levels of sFlt\u20101, sEng, PlGF and cffDNA as compared with controls (<jats:italic>n<\/jats:italic>\u2009=\u200942). Areas under the receiver operating characteristic curves [AUC, Standard error (<jats:italic>SE<\/jats:italic>)] for predicting PE were for marker measurements prior to the first stage of labor as follows: sFlt\u20101 0.97 (<jats:italic>SE<\/jats:italic> 0.02), sEng 0.91 (<jats:italic>SE<\/jats:italic> 0.04), PlGF 0.95 (<jats:italic>SE<\/jats:italic> 0.04), cell\u2010free fetal DNA (DYS 14) 0.84 (<jats:italic>SE<\/jats:italic> 0.06), total cell\u2010free DNA (glyceraldehyde 3\u2010phosphate dehydrogenase) 0.61 (<jats:italic>SE<\/jats:italic> 0.07), sP\u2010selectin 0.51 (<jats:italic>SE<\/jats:italic> 0.07). The discrimination could be slightly improved by using the slt1\u2010PlGF ratio: 0.98 (<jats:italic>SE<\/jats:italic> 0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The sFlt\u20101 is a useful tool for the detection of late\u2010onset PE at triage. This can be slightly improved using a sFlt\u20101\/PIGF ratio. The addition of other biomarkers did not improve screening performance for late\u2010onset PE. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.3995","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T15:36:07Z","timestamp":1351524967000},"page":"1288-1294","source":"Crossref","is-referenced-by-count":13,"title":["Can detection of late\u2010onset PE at triage by sflt\u20101 or PlGF be improved by the use of additional biomarkers?"],"prefix":"10.1002","volume":"32","author":[{"given":"Ines","family":"Kaufmann","sequence":"first","affiliation":[{"name":"Laboratory for Prenatal Medicine, Department of Biomedicine\/Department of Obstetrics and Gynecology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Rusterholz","sequence":"additional","affiliation":[{"name":"Laboratory for Prenatal Medicine, Department of Biomedicine\/Department of Obstetrics and Gynecology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"H\u00f6sli","sequence":"additional","affiliation":[{"name":"Laboratory for Prenatal Medicine, Department of Biomedicine\/Department of Obstetrics and Gynecology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinuhe","family":"Hahn","sequence":"additional","affiliation":[{"name":"Laboratory for Prenatal Medicine, Department of Biomedicine\/Department of Obstetrics and Gynecology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olav","family":"Lapaire","sequence":"additional","affiliation":[{"name":"Laboratory for Prenatal Medicine, Department of Biomedicine\/Department of Obstetrics and Gynecology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17987-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181b7b242"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)01125-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641950902968635"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1111726"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.11.022"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.107607"},{"issue":"1","key":"e_1_2_6_9_1","first-page":"1","article-title":"Saving mothers' lives: reviewing maternal deaths to make motherhood safer: 2006\u20102008. 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