{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:30:40Z","timestamp":1780374640386,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T00:00:00Z","timestamp":1356480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the alteration in epidermal growth factor\u2010like domain 7 (EGFL7) mRNA expression in maternal blood from pregnancies affected by early\u2010onset intrauterine growth restriction (IUGR) at 20\u201324\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Case\u2013control study encompassing six women with pregnancies affected by IUGR (cases) matched in a 1\u2009:\u20097 ratio for gestational age and fetal gender with 42 controls. We quantified EGFL7 mRNA expression in normal and IUGR patients. Matched rank\u2013sum analysis and multiples of median were used to evaluate differences of the marker of interest between cases and controls. Spearman regression analysis was used to correlate the estimated fetal weight at blood sampling with the EGFL7 mRNA values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean observed rank in the IUGR group was significantly higher than that of controls (6.67 vs 4.19, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). Pregnancies affected with IUGR exhibited 1.70\u2010fold higher levels of maternal EGFL7 mRNA compared with matched controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.014). EGFL7 mRNA values were inversely correlated with estimated fetal weight (Spearman's <jats:italic>\u03c1<\/jats:italic>\u2009=\u2009\u22120.429, <jats:italic>p<\/jats:italic>\u2009=\u20090.198).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early IUGR at 20\u201324\u2009weeks\u2019 gestation is associated with higher values of EGFL7 expression in maternal plasma. \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4034","type":"journal-article","created":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T11:27:49Z","timestamp":1356521269000},"page":"168-172","source":"Crossref","is-referenced-by-count":12,"title":["Circulating mRNA for epidermal growth factor\u2010like domain 7 (EGFL7) in maternal blood and early intrauterine growth restriction. A preliminary analysis"],"prefix":"10.1002","volume":"33","author":[{"given":"Margherita","family":"Zanello","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery (DIMEC) Obstetrics and Gynecology University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"DeSanctis","sequence":"additional","affiliation":[{"name":"Department of Specialistic, Diagnostic and Experimental Medicine University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Pula","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery (DIMEC) Obstetrics and Gynecology University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Zucchini","sequence":"additional","affiliation":[{"name":"Department of Specialistic, Diagnostic and Experimental Medicine University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carla","family":"Pittalis","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery (DIMEC) Obstetrics and Gynecology University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery (DIMEC) Obstetrics and Gynecology University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Farina","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery (DIMEC) Obstetrics and Gynecology University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,26]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00327-5"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.86.5.707"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7143.1483"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(00)90000-6"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904223401603"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00171-4"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2008.02.006"},{"key":"e_1_2_3_9_1","doi-asserted-by":"crossref","unstructured":"FigueroaH LozanoM SuazoC et al.Intrauterine growth restriction modifies the normal gene expression in kidney from rabbit fetuses. 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