{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T09:10:10Z","timestamp":1714900210884},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T00:00:00Z","timestamp":1359504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the study was to measure the degree of premaxillary protrusion in fetuses with orofacial clefts of various severities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The maxilla\u2013nasion\u2013mandible (MNM) angle was measured retrospectively on by multiplanar corrected volumes. Sixty\u2010two fetuses with orofacial clefts and known outcome volumes of the fetal head were available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 48 of the 62 cases, the MNM angle could be measured [mean gestational age 23 (range, 18\u201330)\u2009weeks]. The mean MNM angle was normal in all nine cases with cleft lip and intact alveolar ridge (15.2\u00b0; range, 12.5\u00b0\u2013\u200916.9\u00b0). In 24 cases with unilateral cleft lip with or without cleft palate (UCL\/P), the mean MNM angle was 20.0\u00b0 (range, 13.3\u201326.2\u00b0), being above the 95th percentile in 79% (<jats:italic>n<\/jats:italic>\u2009=\u200919) and normal in 21% (<jats:italic>n<\/jats:italic>\u2009=\u20095). In 14 bilateral cleft lip and palate (BCL\/P) cases, the mean MNM angle was 26.5\u00b0 (range, 19.2\u00b0\u201333.7\u00b0) and above the 95th percentile in all cases. There was no difference in MNM angle between isolated clefts and clefts associated with other anomalies. In one case with a Tessier 4 cleft, the MNM angle was above the 95th percentile (25.2\u00b0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The premaxilla tends to protrude in both BCL\/P as UCL\/P cases. The degree of protrusion varies greatly, especially in the BCL\/P group. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4062","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T06:35:44Z","timestamp":1359527744000},"page":"354-359","source":"Crossref","is-referenced-by-count":5,"title":["Premaxillary protrusion assessment by the maxilla\u2013nasion\u2013mandible angle in fetuses with facial clefts"],"prefix":"10.1002","volume":"33","author":[{"given":"E. A. P.","family":"de Jong\u2010Pleij","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. R.","family":"Pistorius","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. S. M.","family":"Ribbert","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. C.","family":"Breugem","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery University Medical Utrecht Utrecht The Netherlands"},{"name":"Department of Plastic and Reconstructive Surgery Meander Medical Centre Amersfoort The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bakker","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit University Medical Centre Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Tromp","sequence":"additional","affiliation":[{"name":"Department of Statistics St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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