{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T22:43:22Z","timestamp":1776984202524,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T00:00:00Z","timestamp":1360540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to determine the accuracy of post\u2010mortem magnetic resonance imaging (MRI) and autopsy for confirmation of sonographically detected fetal ventriculomegaly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study uses retrospective review of fetuses with sonographically diagnosed ventriculomegaly, where the pregnancy was terminated and post\u2010mortem examination was performed during a period in which post\u2010mortem MRI was being offered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen cases were identified. In nine (56%), autopsy and\/or post\u2010mortem MRI confirmed the prenatal findings. In the other seven, both autopsy and post\u2010mortem MRI demonstrated no ventriculomegaly, but antenatal MRI confirmed the ultrasound findings in 6\/7 cases where it had been performed. Post\u2010mortem investigations confirmed antenatal findings in 8\/9 cases with severe ventriculomegaly (posterior horn measurement &gt;15\u2009mm), whereas only 2\/7 in which ventriculomegaly was not confirmed had severe ventriculomegaly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Post\u2010mortem examination, both by traditional neuropathological examination, and post\u2010mortem MRI may fail to confirm prenatal ventriculomegaly in around half of cases. The post\u2010mortem MRI findings indicate that this is due to resolution of ventriculomegaly rather than autopsy artefact, and is presumably a consequence of post\u2010mortem fluid redistribution. Parents should be advised before termination of pregnancy that post\u2010mortem confirmation of ventriculomegaly, especially in mild cases, may not be possible. Antenatal MRI may be a better approach for confirming prenatal ultrasound findings. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4065","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T07:10:44Z","timestamp":1360566644000},"page":"360-364","source":"Crossref","is-referenced-by-count":24,"title":["Post\u2010mortem apparent resolution of fetal ventriculomegaly: evidence from magnetic resonance imaging"],"prefix":"10.1002","volume":"33","author":[{"given":"Neil J.","family":"Sebire","sequence":"first","affiliation":[{"name":"Department of Paediatric Pathology Great Ormond Street Hospital and UCL Institute of Child Health  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Miller","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit UCLH NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas S.","family":"Jacques","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pathology Great Ormond Street Hospital and UCL Institute of Child Health  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Imaging Great Ormond Street Hospital and UCL Institute of Child Health  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet M.","family":"Rennie","sequence":"additional","affiliation":[{"name":"Neonatal Unit UCLH NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giles","family":"Kendall","sequence":"additional","affiliation":[{"name":"Neonatal Unit UCLH NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyn S.","family":"Chitty","sequence":"additional","affiliation":[{"name":"Department of Clinical Molecular Genetics Unit 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