{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:02:30Z","timestamp":1762866150979},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T00:00:00Z","timestamp":1361750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyze the outcomes of fetuses referred because of short femur length.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of all singleton pregnancies referred to a tertiary care referral hospital with a femur length below the 5<jats:sup>th<\/jats:sup> percentile. All ultrasound scan reports, including Doppler, fetal karyotyping, pregnancy outcome and neonatal data were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 112 patients, 87 (78%) had an isolated short femur and 25 (22%) had a non\u2010isolated short femur. The non\u2010isolated cases consisted of chromosomal disorders (n\u2009=\u20096), skeletal abnormalities (n\u2009=\u20096), multiple abnormalities (n\u2009=\u200912) and 1 genetic disorder. In the isolated group 37 cases (43%) were intrauterine growth restricted (positive likelihood ratio 1.20, negative likelihood ratio 0.45). In 33 cases the short femur was unexplained and 17 referrals were considered false\u2010positive. The growth restricted group had significant more abnormal Doppler measurements (p\u2009=\u20090.01), caesarean deliveries (p\u2009=\u20090.043) and admissions to the neonatal intensive care unit (p\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An isolated short femur is associated with intrauterine growth restriction and adverse pregnancy outcome. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4068","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T05:00:40Z","timestamp":1361854840000},"page":"365-370","source":"Crossref","is-referenced-by-count":22,"title":["Association of isolated short fetal femur with intrauterine growth restriction"],"prefix":"10.1002","volume":"33","author":[{"given":"N.","family":"Vermeer","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology VU Medical Center, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. N.","family":"Bekker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology VU Medical Center, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2004.028"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90487-4"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2003.22.3.255"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200003)20:3<210::AID-PD784>3.0.CO;2-4"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5265"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.00015.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20889"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5349"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000253215.79121.75"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70513-8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2011.01299.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2004.02.009"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5225"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2009.09.008"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)35159-3"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000263625"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1868"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000271693"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904223401603"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200606000-00009"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)90690-5"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1997.25.1.17"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.08.055"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.177.1.2399317"},{"key":"e_1_2_5_26_1","first-page":"15","article-title":"New definition of small for gestational age based on fetal growth potential","volume":"65","author":"Gardosi J","year":"2006","journal-title":"Horm Res"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4068","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4068","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.4068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T12:08:36Z","timestamp":1696680516000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.4068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,25]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1002\/pd.4068"],"URL":"https:\/\/doi.org\/10.1002\/pd.4068","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,25]]}}}