{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:49:33Z","timestamp":1760906973918},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T00:00:00Z","timestamp":1360800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to study vaginal fluid phosphorylated insulin\u2010like growth factor binding protein\u20101 (phIGFBP\u20101) testing in early pregnancy to predict spontaneous preterm delivery (PTD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Vaginal and cervical swab samples were collected from 5180 unselected women during the first\u2010trimester (mean gestational age 13.1\u2009weeks) ultrasound screening. PhIGFBP\u20101 was measured in vaginal and cervical fluid by an immunoenzymometric assay. Concentrations of \u226510\u2009\u00b5g\/L were considered elevated. The outcome measure was spontaneous PTD at &lt;32 or &lt;37\u2009weeks gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median concentrations of first\u2010trimester vaginal and cervical phIGFBP\u20101 were higher in women with spontaneous PTD at &lt;32 and &lt;37\u2009weeks gestation. When 10\u2009\u00b5g\/L of phIGFBP\u20101 was used as a cut\u2010off level, the OR in predicting PTD at &lt;32\u2009weeks gestation was 8.6 (95% CI 3.6\u201320.7) for vaginal samples and 3.6 (95% CI 1.7\u20137.9) for cervical samples. At &lt;37\u2009weeks gestation, the OR in predicting PTD was 3.0 (95% CI 1.9\u20133.9) for vaginal samples and 1.9 (95% CI 1.4\u20132.5) for cervical samples. In multiple logistic regression analysis, both elevated vaginal and cervical fluid phIGFBP\u20101 levels were independent predictors of PTD both at &lt;32 and &lt;37\u2009weeks gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>First\u2010trimester vaginal phIGFBP\u20101 performed better than cervical phIGFBP\u20101 in the prediction of spontaneous PTD. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4072","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T08:05:09Z","timestamp":1360829109000},"page":"378-383","source":"Crossref","is-referenced-by-count":8,"title":["Early pregnancy vaginal fluid phosphorylated insulin\u2010like growth factor binding protein\u20101 predicts preterm delivery"],"prefix":"10.1002","volume":"33","author":[{"given":"Hanna","family":"Kallioniemi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena","family":"Rahkonen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oskari","family":"Heikinheimo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorma","family":"Paavonen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Helsinki University Central Hospital  Helsinki 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