{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T14:52:35Z","timestamp":1758811955397},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this research was to evaluate the ability of three\u2010dimensional (3D) ultrasound for demonstrating the palate of fetuses at high risk for cleft palate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Fifty\u2010seven fetuses at high risk for cleft palate were referred for specialist ultrasound at 12\u201340\u2009weeks' gestation. A detailed assessment of palate was made using both two\u2010dimensional and 3D ultrasounds on the axial plane. Antenatal diagnoses were compared with postnatal findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cleft palate was suspected in 13 (22.8%); a normal palate was demonstrated in 38 (67%), and in six (10.2%), the palate view could not be obtained. Mean gestational age at the first visit was 27\u2009weeks 6\u2009days (range of 12\u201340\u2009weeks 3\u2009days). Examination after delivery revealed that one of the 38 fetuses with presumed normal palate had a cleft hard palate, and one had a cleft soft palate (false negative 5%). Among the 13 fetuses with suspected cleft palate, three had an intact palate (false\u2010positive 23%). Sensitivity, specificity, positive predictive value, and negative predictive value of detection of palatal clefts were 71.4%, 91.9%, 62.5%, and 94.4%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using 3D technology, we diagnosed a cleft palate in 83% of high\u2010risk cases, with 5% false negative. 3D technology might produce some technical artifacts resulting in a 23% false\u2010positive rate. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4083","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T07:42:21Z","timestamp":1363246941000},"page":"436-441","source":"Crossref","is-referenced-by-count":13,"title":["Three\u2010dimensional ultrasound demonstration of the fetal palate in high\u2010risk patients: the accuracy of prenatal visualization"],"prefix":"10.1002","volume":"33","author":[{"given":"Liat","family":"Gindes","sequence":"first","affiliation":[{"name":"Department 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