{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T18:18:17Z","timestamp":1773944297915,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T00:00:00Z","timestamp":1363564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to develop a model to adjust the increased \u03b2\u2010hCG levels observed in renal\u2010transplanted women, leading to increased false\u2010positive rates in Down syndrome screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Detailed data from 11 renal\u2010transplanted and a nested\u2010cohort of 70 pregnant women, matched by age, parity and gestational age were retrieved from our hospital records. Patient's age, multiples of the median (MoM) values for free\u03b2\u2010hCG, pregnancy\u2010associated plasma protein\u2010A, nuchal translucency, and creatinine concentration and clearance were noted. Free\u03b2\u2010hCG levels were adjusted according to the deviation of serum creatinine concentration by means of three different methods (median, proportionality and regression). Subsequently, Down syndrome risk was estimated with the three resulting adjusted f\u03b2\u2010hCG values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjustment, the median \u03b2\u2010hCG MoM decreased from 2.15 MoM to 1.00 MoM (median method), 1.61 MoM (proportionality method) or 1.16 MoM (regression method). The non\u2010adjusted 27% false\u2010positive rate dropped to 18% (median method) and 10% (proportionality or regression methods) after re\u2010estimation of the Down syndrome risk. In controls, the observed median for \u03b2\u2010hCG MoM was 1.12, and the false\u2010positive rate was 5.7%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In first\u2010trimester Down syndrome screening, f\u03b2\u2010hCG adjustment by the regression method appears to be the best to match with controls. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4089","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T06:42:51Z","timestamp":1363588971000},"page":"467-470","source":"Crossref","is-referenced-by-count":4,"title":["First\u2010trimester Down syndrome screening in renal\u2010transplanted pregnant women: a model for adjusting the false\u2010positives rates"],"prefix":"10.1002","volume":"33","author":[{"given":"Maribel","family":"Grande","sequence":"first","affiliation":[{"name":"Department of Maternal\u2010Fetal Medicine Institute Gynecology, Obstetrics and Neonatology, Hospital Cl\u00ednic  Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicen\u00e7","family":"Cararach","sequence":"additional","affiliation":[{"name":"Department of Maternal\u2010Fetal Medicine Institute Gynecology, Obstetrics and Neonatology, Hospital Cl\u00ednic  Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Casals","sequence":"additional","affiliation":[{"name":"Centre de Diagn\u00f2stic Biom\u00e8dic  Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Borrell","sequence":"additional","affiliation":[{"name":"Department of Maternal\u2010Fetal Medicine Institute Gynecology, Obstetrics and Neonatology, Hospital Cl\u00ednic  Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199605)16:5<405::AID-PD868>3.0.CO;2-Y"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)24044-4"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.294"},{"key":"e_1_2_5_5_1","first-page":"15","volume":"6","author":"Spencer K.","year":"1999","journal-title":"Renal problems. 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