{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:07:47Z","timestamp":1791356867491,"version":"4.3.1"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the outcome of maternal primary cytomegalovirus (CMV) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of a cohort of 238 patients with maternal primary CMV infection detected at routine screening. The cases were managed with serial ultrasound (US) scans, and amniocentesis was performed in 36.1% of cases. All prenatal results were confirmed at birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average age was 31.9 (18\u201344) years. Patients were symptomatic in 21% of cases. The rate of intrauterine transmission was 24.9%, and it was 8.8%, 19%, 30.6%, 34.1% and 40% in the preconceptional period, the periconceptional period, and the first, second and third trimesters of pregnancy, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.025). There was a significantly higher risk of US abnormalities when maternal infection occurred during the preconceptional or periconceptional period and the first trimester compared with later (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Because of US abnormalities, pregnancy was terminated in 18 cases at the parents' request. Three infected newborns were symptomatic; all three cases were suspected at US before birth. We did not observe any symptomatic fetal infection when maternal infection occurred after 14\u2009weeks of gestation. A number of clinically asymptomatic cases (5.5%) developed hearing loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rate of materno fetal transmission is linearly correlated to the gestational age at infection. No severe case of congenital infection was observed if maternal infection occurred after 14\u2009weeks of gestation. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4118","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T02:43:04Z","timestamp":1364956984000},"page":"751-758","source":"Crossref","is-referenced-by-count":231,"title":["A series of 238 cytomegalovirus primary infections during pregnancy: description and outcome"],"prefix":"10.1002","volume":"33","author":[{"given":"O.","family":"Picone","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology H\u00f4pital Foch  Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Vauloup\u2010Fellous","sequence":"additional","affiliation":[{"name":"INSERM U764 Universit\u00e9 Paris\u2010Sud, AP\u2010HP, Microbiology Department, H\u00f4pital Antoine B\u00e9cl\u00e8re  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G.","family":"Cordier","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology AP\u2010HP, Antoine B\u00e9cl\u00e8re Hospital  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Guitton","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology H\u00f4pital Foch  Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V.","family":"Senat","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology H\u00f4pital Bic\u00eatre, Assistance Publique H\u00f4pitaux de Paris (AP\u2010HP)  Le Kremlin\u2010Bic\u00eatre France"},{"name":"Inserm CESP Centre for Research in Epidemiology and Population Health, U1018, Reproduction and Child Development  Villejuif France"},{"name":"University Paris\u2010Sud  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology H\u00f4pital Bic\u00eatre, Assistance Publique H\u00f4pitaux de Paris (AP\u2010HP)  Le Kremlin\u2010Bic\u00eatre France"},{"name":"Inserm CESP Centre for Research in Epidemiology and Population Health, U1018, Reproduction and Child Development  Villejuif France"},{"name":"University Paris\u2010Sud  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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