{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:59:23Z","timestamp":1767851963259,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T00:00:00Z","timestamp":1368489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the prognostic value of fetal serum <jats:italic>\u03b1<\/jats:italic>1\u2010microglobulin with that of <jats:italic>\u03b2<\/jats:italic>2\u2010microglobulin and cystatin C for postnatal renal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Retrospective study of <jats:italic>\u03b1<\/jats:italic>1\u2010microglobulin, <jats:italic>\u03b2<\/jats:italic>2\u2010microglobulin, and cystatin C in fetal serum from 126 fetuses with congenital abnormalities of the kidney and urinary tract (73 and 53, respectively). Two groups were defined: group with normal renal function and group with renal failure. For live born infants, renal function was assessed on the basis of serum creatinine (cutoff 50\u2009\u00b5mol\/L) or glomerular filtration rate (cutoff 75\u2009mL\/min\/1.73\u2009m2) or both. In case of infant or fetal death, histological kidney lesions were considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were observed for the three markers between fetuses with good renal prognosis and those with renal failure (34.4\u2009mg\/L vs 67.6\u2009mg\/L for <jats:italic>\u03b1<\/jats:italic>1\u2010microglobulin, respectively; 3.9\u2009mg\/L vs 7.35\u2009mg\/L, for <jats:italic>\u03b2<\/jats:italic>2\u2010microglobulin, respectively; and 1.67\u2009mg\/L vs 2.12\u2009mg\/L for cystatin C, respectively). Areas under receiver operator curves were used to compare the three markers, 0.96, 0.90, and 0.74 for <jats:italic>\u03b2<\/jats:italic>2\u2010microglobulin, <jats:italic>\u03b1<\/jats:italic>1\u2010microglobulin, and cystatin C, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although <jats:italic>\u03b1<\/jats:italic>1\u2010microglobulin is significantly different in fetuses with good renal prognosis and those with renal failure, overall, it is a less reliable prognostic marker than fetal serum <jats:italic>\u03b2<\/jats:italic>2\u2010microglobulin. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4128","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T14:06:47Z","timestamp":1366121207000},"page":"775-781","source":"Crossref","is-referenced-by-count":16,"title":["Fetal serum <i>\u03b1<\/i>\u20101 microglobulin for renal function assessment: comparison with <i>\u03b2<\/i>2\u2010microglobulin and cystatin C"],"prefix":"10.1002","volume":"33","author":[{"given":"Claire","family":"Nguyen","sequence":"first","affiliation":[{"name":"Biochimie\u2010Hormonologie H\u00f4pital Robert Debr\u00e9 AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Dreux","sequence":"additional","affiliation":[{"name":"Biochimie\u2010Hormonologie H\u00f4pital Robert Debr\u00e9 AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Heidet","sequence":"additional","affiliation":[{"name":"Nephrologie P\u00e9diatrique, Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales H\u00e9r\u00e9ditaires de l'Enfant et de l'Adulte H\u00f4pital Necker Enfants\u2010Malades AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Czerkiewicz","sequence":"additional","affiliation":[{"name":"Biochimie\u2010Hormonologie 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