{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:08:17Z","timestamp":1769634497650,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000690","name":"Research Councils UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The goal of this study is to investigate women's preferences and information needs for routine implementation of fetal Rhesus D (RhD) typing using cell\u2010free fetal DNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A questionnaire was developed following focus groups and interviews with both health professionals and RhD negative (RhD\u2212) women offered fetal RhD genotyping within a research study and distributed to RhD\u2212 women attending routine antenatal appointments in four National Health Service hospitals. Current knowledge of blood types, anti\u2010D administration, fetal RhD genotyping and future practices were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 19 respondents participated in interviews and focus groups, and 270 respondents completed the questionnaires. Questionnaire respondents overwhelmingly felt that the test should be offered to all RhD\u2212 women (92.1%), and 75.9% said that they would accept this test. Most were happy to have the test even if it involved extra blood tests (89.3%) or appointments (79%). The knowledge of blood groups was poor. Although 90.7% knew that the baby could have a different blood group from themselves, only 34% knew that blood groups are inherited from both parents. More than 40% were not aware that anti\u2010D would not be required if their baby was RhD\u2212.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women would welcome the introduction of routine fetal RhD genotyping. Information leaflets and training of midwives will be essential for implementation to ensure good understanding regarding testing. \u00a9 2013 The Authors. <jats:italic>Prenatal Diagnosis<\/jats:italic> published by John Wiley &amp; Sons Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4135","type":"journal-article","created":{"date-parts":[[2013,4,27]],"date-time":"2013-04-27T05:24:37Z","timestamp":1367040277000},"page":"688-694","source":"Crossref","is-referenced-by-count":20,"title":["Routine testing of fetal Rhesus D status in Rhesus D negative women using cell\u2010free fetal DNA: an investigation into the preferences and information needs of women"],"prefix":"10.1002","volume":"33","author":[{"given":"Kerry","family":"Oxenford","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Silcock","sequence":"additional","affiliation":[{"name":"Women's Health Division University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Hill","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit University College London Hospitals NHS Foundation Trust  London UK"},{"name":"Clinical and Molecular Genetics Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyn","family":"Chitty","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit University College London Hospitals NHS Foundation Trust  London UK"},{"name":"Clinical and Molecular Genetics Unit UCL Institute of Child Health  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,20]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"National Institute for Clinical Excellence (NICE).Technology appraisal guidance 41. Guidance on the use of routine antenatal anti\u2010D prophylaxis for RhD\u2010negative women. London: NICE 2002."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470987018"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-3274(02)00066-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904223401602"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)02174-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2172"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39518.463206.25"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2011.300160.36"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03362.x"},{"key":"e_1_2_7_11_1","unstructured":"National Institute for Clinical Excellence (NICE).Technology Appraisal Guidance 156. Routine antenatal anti\u2010D prophylaxis for women who are Rhesus D negative. London: NICE;2008[Accessed 13\/04\/2012]; Available from:http:\/\/www.nice.org.uk\/nicemedia\/live\/12047\/41690\/41690.pdf."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"issue":"1","key":"e_1_2_7_13_1","first-page":"58","article-title":"Routine fetal RHD typing using cffDNA in RhD negative women: timing, costs and efficiency","volume":"32","author":"Chitty LS","year":"2012","journal-title":"Prenat Diagn"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.50"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3893"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02653.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331254"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2888"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2205"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2835"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-8-49"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4135","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.4135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.4135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.4135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T21:02:26Z","timestamp":1694638946000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.4135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,20]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1002\/pd.4135"],"URL":"https:\/\/doi.org\/10.1002\/pd.4135","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,20]]}}}