{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:27:29Z","timestamp":1761895649024},"reference-count":7,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T00:00:00Z","timestamp":1369872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p><jats:bold>What's already known about this topic?<\/jats:bold> \n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>In de novo cases of genodermatoses, direct prenatal ultrasound may lead to a strong suspicion in only very few cases, mainly represented by the most severe form of congenital ichthyosis. For others, including epidermolysis bullosa and disorders of pigmentation, fetal skin lesions are not accessible to prenatal ultrasound examination.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><jats:p><jats:bold>What does this study add?<\/jats:bold> \n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Certain prenatal diagnosis of <jats:italic>de novo<\/jats:italic> cases of epidermolysis bullosa is feasible when all biological and clinical patterns are present without the need for histological confirmation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These cardinal signs are represented by (1) unexplained polyhydramnios with high AFP levels in the amniotic fluid (&gt;20\u2009MoM), (2) the presence of an unusual addition slow band on acetylcholinesterase electrophoresis and (3) the presence of a dilated stomach suggestive of pyloric atresia.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p>","DOI":"10.1002\/pd.4137","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T07:23:42Z","timestamp":1366788222000},"page":"908-909","source":"Crossref","is-referenced-by-count":9,"title":["The key role of ultrasound examination in the prenatal diagnosis of epidermolysis bullosa with pyloric atresia"],"prefix":"10.1002","volume":"33","author":[{"given":"Paul","family":"Maurice","sequence":"first","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2010Obst\u00e9trique et Centre Pluridisciplinaire de Diagnostic Pr\u00e9natal de l\u2019 Est Parisien H\u00f4pital Armand Trousseau, APHP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Eyrolle\u2010Guignot","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2010Obst\u00e9trique Centre Hospitalier  Papeete 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