{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:30:35Z","timestamp":1789054235011,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T00:00:00Z","timestamp":1373414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the relationship between maternal serum pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A) in the first trimester of pregnancy and the development of preeclampsia (PE), early PE, small\u2010for\u2010gestational age (SGA) fetus and preterm delivery (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This is a retrospective study of 12\u2009355 pregnant women that delivered between 2008 and 2011. We define the first, third and fifth percentiles of maternal serum PAPP\u2010A multiples of the median (MoM). The primary outcome measures were the occurrence of PE, early PE (PE requiring delivery before 34\u2009weeks), SGA fetus (birth weight\u2009&lt;\u20095th centile) and PD. The Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test and chi\u2010squared test were used to analyze continuous and dichotomous variables, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal serum PAPP\u2010A was significantly lower in women with PE, early PE, SGA fetus and PD (0.91, 0.74, 0.80 and 0.84 MoM, respectively) than in the study population (0.99 MoM) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The lower the MoM percentile of PAPP\u2010A, the higher are the odds ratio (OR) to develop PE, early PE, SGA fetus and PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maternal serum PAPP\u2010A levels are lower in women who develop preeclampsia, those with SGA fetus and those who deliver preterm. However, on its own, maternal serum PAPP\u2010A performs poorly (OR for PE between 1.76 and 2.41 with the lower percentile of PAPP\u2010A) as a screening test for these conditions. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4141","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T00:40:42Z","timestamp":1366764042000},"page":"839-847","source":"Crossref","is-referenced-by-count":57,"title":["Association between first\u2010trimester maternal serum pregnancy\u2010associated plasma protein\u2010A and obstetric complications"],"prefix":"10.1002","volume":"33","author":[{"given":"Francesco","family":"D'Antonio","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, Division of Developmental Sciences St. George's University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Rijo","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Division 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