{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:07:49Z","timestamp":1781269669813,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T00:00:00Z","timestamp":1368662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was designed to assess the accuracy of ultrasound anatomy screening before 17\u2009weeks gestation in a population at high risk of fetal anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of anatomy ultrasound examinations carried out between 12\u201317\u2009weeks gestation in a high\u2010risk population. Early sonographic findings were compared with the 18\u201322\u2009week anatomy ultrasound, karyotype, echocardiogram and postnatal\/postmortem results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A complete anatomical survey was achieved in 68 of 101 screened fetuses (67%), with cardiac anatomy having the lowest completion rate (78\/101; 77%). Anomalies were suspected on ultrasound in 23 fetuses. Four of these did not undergo pathologic examination but had clearly abnormal findings on ultrasound. Eighteen fetuses had a confirmed abnormal outcome. Sensitivity of early anatomy ultrasound was 83.3% (<jats:italic>n<\/jats:italic>\u2009=\u200915\/18) and specificity 94.9% (<jats:italic>n<\/jats:italic>\u2009=\u200975\/79). There were 3 false negative ultrasounds (16.6%: trisomy 21 with short humerus, choanal atresia and ventriculomegaly, and a ventricular septal defect). False positive rate was 4.0% (4 ventricular septal defects).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The high rate of visualization of anatomic structures between 12\u201317\u2009weeks gestation allows for either early detection of fetal anomalies or parental reassurance in many cases. Subtle anomalies of the heart remain difficult to diagnose. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4145","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T05:11:35Z","timestamp":1368076295000},"page":"863-868","source":"Crossref","is-referenced-by-count":12,"title":["Early anatomy ultrasound in women at increased risk of fetal anomalies"],"prefix":"10.1002","volume":"33","author":[{"given":"Janice","family":"Lim","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics &amp; Gynaecology, Mount Sinai Hospital University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy L.","family":"Whittle","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics &amp; Gynaecology, Mount Sinai Hospital University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee\u2010Man","family":"Lee","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics &amp; Gynaecology, Mount Sinai Hospital University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Ryan","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics &amp; Gynaecology, Mount Sinai Hospital University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Van Mieghem","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics &amp; Gynaecology, Mount Sinai Hospital University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6840.1474"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.14020092.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.587058"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2685"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2709"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349.2010.517307"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2642"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.664199"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.007"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.241035027"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8831"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00454.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970120704"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.184"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2004.23.8.1019"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7444"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8934"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2012.06.002"},{"key":"e_1_2_5_20_1","first-page":"761","article-title":"Closure of the cerebellar vermis: evaluation with second trimester US","volume":"3","author":"Bromley B","year":"1993","journal-title":"Radiology"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.09.003"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.12.006"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2012.10.013"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7720"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8963"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(00)00168-9"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4145","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.4145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T02:17:08Z","timestamp":1696904228000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.4145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,16]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1002\/pd.4145"],"URL":"https:\/\/doi.org\/10.1002\/pd.4145","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,16]]}}}