{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:04:20Z","timestamp":1783069460330,"version":"3.54.6"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T00:00:00Z","timestamp":1371081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to describe the nature of central nervous system (CNS) anomalies diagnosed during the third trimester following a normal anatomy scan at 21\u201324\u2009weeks of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study of all pregnant women referred to the fetal medicine unit at Sheba Medical Center between 2005 and 2011 due to fetal CNS anomalies detected at the late second and third trimesters following a normal anatomy scan at 21\u201324\u2009weeks of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 47 patients were diagnosed with fetal CNS anomalies at a median gestational age of 31.1\u2009weeks (range 24\u201338). The four most common anomalies found included intracranial cysts (19%), mild ventriculomegaly (15%), absence or dysgenesis of the corpus callosum (10%), and intracerebral hemorrhage (10%). Other CNS anomalies detected in this group of patients included hydrocephalus, Dandy walker malformation, large cysterna magna, microcephalus with lissencephaly, craniosynestosis, periventricular pseudocysts, global brain ischemia, cerebellar hypoplasia, and sub\u2010ependymal nodule.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fetal brain continues to evolve throughout gestation, and therefore, some of the CNS anomalies can be diagnosed only during late second and third trimesters of pregnancy. Consequently, in patients who have a third trimester scan for any reason, assessment of the fetal CNS should be considered. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4163","type":"journal-article","created":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T17:23:06Z","timestamp":1369416186000},"page":"929-934","source":"Crossref","is-referenced-by-count":39,"title":["Late diagnosis of fetal central nervous system anomalies following a normal second trimester anatomy scan"],"prefix":"10.1002","volume":"33","author":[{"given":"Y.","family":"Yinon","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center Tel\u2010Aviv University  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Katorza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center Tel\u2010Aviv University  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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