{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T13:40:53Z","timestamp":1770298853436,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T00:00:00Z","timestamp":1372204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the association between serum pregnancy\u2010associated plasma protein A (PAPP\u2010A) and free \u03b2\u2010human chorionic gonadotropin (free \u03b2\u2010hCG) in the first trimester and perinatal complications in post\u2010date pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 4948 women, who delivered after 40 gestational weeks, were included. Labour was not induced routinely until 42\u2009weeks. Serum levels of PAPP\u2010A and free \u03b2\u2010hCG were determined at the first\u2010trimester screening for Down syndrome. Neonatal complications were obtained from specific registration forms filled out by senior neonatologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In post\u2010date pregnancies, PAPP\u2010A\u2009&lt;\u20090.4 multiples of the median was associated with Apgar score of less than 7 at 5\u2009min (OR<jats:sub>adj<\/jats:sub> 5.4, 95% CI 2.0\u201314.3), admission to the neonatal intensive care unit (OR<jats:sub>adj<\/jats:sub> 1.5, 95% CI 1.0\u20132.3) and newborn hypoglycaemia (OR<jats:sub>adj<\/jats:sub> 3.4, 95% CI 1.8\u20136.4). In small for gestation (SGA) neonates, the risk of hypoglycaemia was further increased (OR 14.6, 95% CI 3.4\u201358.0). Similar analyses were made with free \u03b2\u2010hCG, but no statistically significant associations were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low first\u2010trimester serum PAPP\u2010A was associated with increased neonatal morbidity in post\u2010date pregnancies, particularly in newborns with SGA. Thus, PAPP\u2010A may qualify the timing of induction of labour in these pregnancies. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4174","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T19:28:22Z","timestamp":1370460502000},"page":"965-972","source":"Crossref","is-referenced-by-count":6,"title":["Pregnancy\u2010associated plasma protein A levels and neonatal complications in post\u2010date pregnancies"],"prefix":"10.1002","volume":"33","author":[{"given":"Anne R.","family":"Zizzo","sequence":"first","affiliation":[{"name":"Perinatal Epidemiology Research Unit Aarhus University Hospital  Skejby Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Kirkegaard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Aarhus University Hospital  Skejby Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tine 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