{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:51:16Z","timestamp":1787169076670,"version":"build-2736575974"},"reference-count":8,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>\n                    <jats:bold>What's already known about this topic?<\/jats:bold>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Megalencephaly\u2010capillary malformation (MCAP) syndrome is a rare disorder characterized by growth dysregulation, central nervous system and vascular anomalies, and distal limb malformations. Disruption of PI3K\u2010AKT signaling has recently been implicated as the cause of MCAP.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>What does this study add?<\/jats:bold>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>This study reports a case of MCAP with bilateral pleural effusions and fetal hydrops managed with thoracoamniotic shunt placement, highlights characteristic features of MCAP that may facilitate prenatal diagnosis, and discusses the possibility of prenatal molecular diagnosis in future cases.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1002\/pd.4178","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T02:56:50Z","timestamp":1370919410000},"page":"1010-1012","source":"Crossref","is-referenced-by-count":10,"title":["Expanding the differential diagnosis of fetal hydrops: an unusual prenatal presentation of megalencephaly\u2010capillary malformation syndrome"],"prefix":"10.1002","volume":"33","author":[{"given":"Daniel T.","family":"Swarr","sequence":"first","affiliation":[{"name":"Division of Human Genetics, Department of Pediatrics University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia  Philadelphia PA USA"},{"name":"Division of Neonatology, Department of Pediatrics University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahla","family":"Khalek","sequence":"additional","affiliation":[{"name":"Department of Surgery Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"},{"name":"Center for Fetal Diagnosis and Treatment The Children's Hospital of Philadelphia  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Treat","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret A.","family":"Horton","sequence":"additional","affiliation":[{"name":"Division of Human Genetics, Department of Pediatrics University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghayda M.","family":"Mirzaa","sequence":"additional","affiliation":[{"name":"Center for Integrative Brain Research Seattle Children's Hospital  Seattle Washington WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Baptiste","family":"Riviere","sequence":"additional","affiliation":[{"name":"Center for Integrative Brain Research Seattle Children's Hospital  Seattle Washington WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Dobyns","sequence":"additional","affiliation":[{"name":"Center for Integrative Brain Research Seattle Children's Hospital  Seattle Washington WA, USA"},{"name":"Departments of Neurology and Pediatrics University of Washington  Seattle Washington WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine H.","family":"Zackai","sequence":"additional","affiliation":[{"name":"Division of Human Genetics, Department of Pediatrics University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,23]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34402"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019605-199710000-00001"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2331"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30235"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33514"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20551"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1428"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.4076\/1752-1947-3-9215"}],"container-title":["Prenatal 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