{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T21:48:38Z","timestamp":1771364918123,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T00:00:00Z","timestamp":1375747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate serum\u2010only four\u2010marker first trimester (1T\u2010Quad) Down syndrome screening, alone or contingently to select 10\u201320% with highest risk for nuchal translucency (NT) or cell\u2010free (cf)DNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Stored maternal serum samples (\u221280\u2009\u00b0C) from 90 pregnancies with fetal Down syndrome and 1607 controls were retrieved and measured for placental growth factor, \u03b1\u2010fetoprotein, pregnancy\u2010associated plasma protein and free \u03b2\u2010human chorionic gonadotropin. Samples were from singleton pregnancies (9\u201313\u2009+\u20096\u2009weeks), and NT was measured between 11 and 13\u2009+\u20096\u2009weeks. Markers were expressed in multiples of the normal median (MoM) for gestation. Gaussian models were fitted to the distribution of log MoMs by using observed parameters, standardized maternal age distribution (mean 27, SD 5.5) and published cfDNA results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The model\u2010predicted detection rate (DR) for 1T\u2010Quad was 74% [5% false\u2010positive rate (FPR)]. When used contingently to select for NT, the DR was 89% at 5%. When used to select for cfDNA, the DR was 91% (FPR\u2009&lt;\u20090.05%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 1T\u2010Quad test can achieve a similar DR to a second\u2010trimester Quad test. When used contingently to select for NT, the DR is similar to the Combined test. Used contingently to select for cfDNA would achieve even higher detection. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4194","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T04:56:33Z","timestamp":1373345793000},"page":"1044-1049","source":"Crossref","is-referenced-by-count":30,"title":["First\u2010trimester Down syndrome screening using additional serum markers with and without nuchal translucency and cell\u2010free DNA"],"prefix":"10.1002","volume":"33","author":[{"given":"J","family":"Johnson","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology University of Calgary  Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pastuck","sequence":"additional","affiliation":[{"name":"Coordinator, Early Risk Assessment Program  Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology University of British Columbia  Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Connors","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology University of Calgary  Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Krause","sequence":"additional","affiliation":[{"name":"Calgary Laboratory Services  Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Wilson","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology University of Calgary  Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Cuckle","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Columbia University Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,6]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"146","article-title":"Prenatal screening for fetal aneuploidy","volume":"187","author":"Summers A","year":"2007","journal-title":"Journal Obstet Gynecol Canada"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.148"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6331"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2496"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8881"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335684"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11173"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4087"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046955"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199906)19:6<505::AID-PD572>3.0.CO;2-6"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330198"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c7401"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.12.060"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182368a0e"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31824fb482"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.01.029"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.01.030"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.05.021"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.678442"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.08.033"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4002"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780110211"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.990"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1987.tb03115.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4139"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2894"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341264"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324352"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335677"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.05.024"},{"key":"e_1_2_5_32_1","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1097\/01.AOG.0000423819.85283.f4","article-title":"Noninvasive prenatal testing for fetal aneuploidy. 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