{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T06:55:26Z","timestamp":1781506526177,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,8,4]],"date-time":"2013-08-04T00:00:00Z","timestamp":1375574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Pilot studies have suggested the amount of cell\u2010free fetal DNA (cffDNA) in the maternal serum is increased in pregnancies complicated by placenta accreta. Our objective was to determine if levels of cffDNA can predict invasive placentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled women with antenatally suspected placenta accreta compared with gestational age\u2010matched cases of placenta previa and women with prior cesarean deliveries (CDs) and normal placentation. The fetal fraction of cffDNA was quantified using DANSR\u2122 as compared with total DNA. Patient characteristics were compared between the three groups using ANOVA, and linear regression was used to compare the fraction of cffDNA between pathologically confirmed cases of placenta accreta, placenta previa and normal placentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty women were enrolled, (seven cases of placenta accreta, six cases of placenta previa and seven cases of normal placentation with prior CD). The groups did not differ by maternal weight, placental weight, number of prior CD or years from prior CD. The mean fraction of cffDNA did not differ significantly by group when controlling for the aforementioned factors (accreta\u2009=\u200919.1%, previa\u2009=\u200927.2%, prior CD\u2009=\u200928.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.26), nor did the median (accreta\u2009=\u200917.0%, previa\u2009=\u200930.1%, prior CD\u2009=\u200922.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We could not confirm diagnostic benefit. Further investigation of other biomarkers including placental mRNA is warranted. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4195","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T04:58:00Z","timestamp":1373345880000},"page":"1050-1053","source":"Crossref","is-referenced-by-count":32,"title":["Fraction of cell\u2010free fetal DNA in the maternal serum as a predictor of abnormal placental invasion\u2010a pilot study"],"prefix":"10.1002","volume":"33","author":[{"given":"Amber","family":"Samuel","sequence":"first","affiliation":[{"name":"The Divisions of Maternal\u2010Fetal Medicine and Gynecologic Oncology, Department of Obstetrics and Gynecology Columbia University Medical Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa","family":"Bonanno","sequence":"additional","affiliation":[{"name":"The Divisions of Maternal\u2010Fetal Medicine and Gynecologic Oncology, Department of Obstetrics and Gynecology Columbia University Medical Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Oliphant","sequence":"additional","affiliation":[{"name":"Ariosa Diagnostics, Inc.  San Jose CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Batey","sequence":"additional","affiliation":[{"name":"Ariosa Diagnostics, Inc.  San Jose CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Wright","sequence":"additional","affiliation":[{"name":"The Divisions of Maternal\u2010Fetal Medicine and Gynecologic Oncology, Department of Obstetrics and Gynecology Columbia University Medical Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000219750.79480.84"},{"key":"e_1_2_5_3_1","first-page":"1","article-title":"Births: preliminary data for 2009","volume":"59","author":"Hamilton BE","year":"2010","journal-title":"Nat Vit Stat Rep"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.074"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e6df64"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181df94fb"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182051db2"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181df94e8"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000233155.62906.6d"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)02174-0"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1700"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.07.063"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/45.2.184"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.596"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.2.239"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/48.2.353"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2922"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.01.030"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346806"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000137352.93110.15"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0637450100"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.047803"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.11.013"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2056"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4195","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4195","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.4195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T21:13:04Z","timestamp":1698700384000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.4195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,4]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1002\/pd.4195"],"URL":"https:\/\/doi.org\/10.1002\/pd.4195","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,4]]}}}