{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:42:37Z","timestamp":1791859357313,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this research was to evaluate the outcome and prognostic value of fetal serum <jats:italic>\u03b2<\/jats:italic>2\u2010microglobulin in case of prenatal diagnosis of severe bilateral renal hypoplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases of hypoplastic kidneys were detected on ultrasound and referred to our laboratory for determination of fetal blood <jats:italic>\u03b2<\/jats:italic>2\u2010microglobulin, over a 12\u2010year period. Prenatal prognostic assessment was based upon amniotic fluid volume and fetal serum <jats:italic>\u03b2<\/jats:italic>2\u2010microglobulin (cut\u2010off: 5\u2009mg\/L). Outcome measures were postnatal renal function or renal pathological features when termination of pregnancy (TOP) and genetic studies were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 34 cases were identified; 13 (38%) were liveborn and 21 (62%) underwent TOP. Renal hypoplasia was confirmed postnatally in all cases. Oligohydramnios\/anhydramnios was observed in 30\/34 (88%) cases. Associated genetic or anatomical anomalies were found in 8\/34 (24%) cases. Renal function of liveborn infants was normal in 4\/13 cases. Renal lesions were observed in all TOPs (21\/21 cases). Overall, 30\/34 (88.2%) cases had a poor outcome. <jats:italic>\u03b2<\/jats:italic>2\u2010microglobulin accurately predicts poor renal outcome in 27\/31 (87.1%) cases. <jats:italic>\u03b2<\/jats:italic>2\u2010microglobulin was not interpretable in three cases due to amniotic fluid contamination. The prognostic value of <jats:italic>\u03b2<\/jats:italic>2\u2010microglobulin was similar to that of amniotic fluid volume assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hypoplastic kidneys complicated by oligohydramnios\/anhydramnios are associated with poor outcome. Fetal serum <jats:italic>\u03b2<\/jats:italic>2\u2010microglobulin and oligohydramnios both predicted poor outcome. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4217","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T18:06:48Z","timestamp":1376417208000},"page":"1167-1172","source":"Crossref","is-referenced-by-count":15,"title":["Outcome following prenatal diagnosis of severe bilateral renal hypoplasia"],"prefix":"10.1002","volume":"33","author":[{"given":"Emmanuel","family":"Spaggiari","sequence":"first","affiliation":[{"name":"Developmental Biology, Robert Debr\u00e9 Hospital AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien J.","family":"Stirnemann","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Necker Enfants\u2010Malades Hospital AP\u2010HP  Paris France"},{"name":"University Paris Descartes  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Heidet","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales H\u00e9r\u00e9ditaires de l'Enfant et de l'Adulte, Pediatric Nephrology, Necker Enfants\u2010Malades Hospital AP\u2010HP  Paris France"},{"name":"University Paris Descartes  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Dreux","sequence":"additional","affiliation":[{"name":"Biochemistry and Hormonology, Robert Debr\u00e9 Hospital AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Ville","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Necker Enfants\u2010Malades Hospital AP\u2010HP  Paris France"},{"name":"University Paris Descartes  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Francois","family":"Oury","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Robert Debr\u00e9 Hospital AP\u2010HP  Paris France"},{"name":"University Paris Diderot and Paris Sorbonne cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Lise","family":"Delezoide","sequence":"additional","affiliation":[{"name":"Developmental Biology, Robert Debr\u00e9 Hospital AP\u2010HP  Paris France"},{"name":"University Paris Diderot and Paris Sorbonne cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Muller","sequence":"additional","affiliation":[{"name":"Biochemistry and Hormonology, Robert Debr\u00e9 Hospital AP\u2010HP  Paris France"},{"name":"University Paris Ile de France Ouest  Versailles Saint\u2010Quentin France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03400411"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-2068-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.37.192.142"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.4.e382"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.157.3.1872242"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.866"},{"key":"e_1_2_6_8_1","first-page":"601","article-title":"Amniotic fluid index measurements during pregnancy","volume":"32","author":"Phelan JP","year":"1987","journal-title":"J Reprod Med"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.142.3.467"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-002-0036-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01640309"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(02)70054-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80177-9"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.56.8.601"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00167.x"},{"key":"e_1_2_6_16_1","first-page":"356","article-title":"Congenital abnormalities of the urinary sytem. 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