{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:10:35Z","timestamp":1771459835248,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p><jats:bold>What's already known about this topic?<\/jats:bold> \n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Noninvasive prenatal <jats:italic>RHD<\/jats:italic> typing can be achieved by using cell\u2010free fetal DNA in the plasma of RhD\u2010negative mothers.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>For RhD\u2010negative mothers carrying intact but dysfunctional <jats:italic>RHD<\/jats:italic> gene variants, the abundant maternal <jats:italic>RHD<\/jats:italic> sequences in maternal plasma could interfere with the fetal <jats:italic>RHD<\/jats:italic> allele detection.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><jats:p><jats:bold>What does this study add?<\/jats:bold> \n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Digital PCR provides a high analytical specificity to noninvasively determine the fetal inheritance of <jats:italic>RHD<\/jats:italic> allele in alloimmunized pregnancies involving maternal <jats:italic>RHD<\/jats:italic> variants.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p>","DOI":"10.1002\/pd.4230","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T21:37:11Z","timestamp":1378157831000},"page":"1214-1216","source":"Crossref","is-referenced-by-count":21,"title":["Noninvasive fetal <i>RHD<\/i> genotyping by microfluidics digital PCR using maternal plasma from two alloimmunized women with the variant <i>RHD<\/i>(IVS3+1G&gt;A) allele"],"prefix":"10.1002","volume":"33","author":[{"given":"Nancy B. Y.","family":"Tsui","sequence":"first","affiliation":[{"name":"Centre for Research into Circulating Fetal Nucleic Acids Li Ka Shing Institute of Health Sciences  Hong Kong China"},{"name":"Department of Chemical Pathology The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"Hyland","sequence":"additional","affiliation":[{"name":"Research and Development Division Australian Red Cross Blood Service  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn J.","family":"Gardener","sequence":"additional","affiliation":[{"name":"Centre for Maternal and Fetal Medicine Mater Health Services, and Mater Medical Research Institute  Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Danon","sequence":"additional","affiliation":[{"name":"Centre for Advanced Prenatal Care Royal Brisbane &amp; Women's Hospital  Queensland Australia"},{"name":"UQ Centre for Clinical Research University of Queensland  Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas M.","family":"Fisk","sequence":"additional","affiliation":[{"name":"Centre for Advanced Prenatal Care Royal Brisbane &amp; Women's Hospital  Queensland Australia"},{"name":"UQ Centre for Clinical Research University of Queensland  Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenda","family":"Millard","sequence":"additional","affiliation":[{"name":"Research and Development Division Australian Red Cross Blood Service  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Flower","sequence":"additional","affiliation":[{"name":"Research and Development Division Australian Red Cross Blood Service  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. 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Dennis","family":"Lo","sequence":"additional","affiliation":[{"name":"Centre for Research into Circulating Fetal Nucleic Acids Li Ka Shing Institute of Health Sciences  Hong Kong China"},{"name":"Department of Chemical Pathology The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,19]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812103392402"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00584.x"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03538.x"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.111385"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810373105"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.60"},{"key":"e_1_2_2_8_1","unstructured":"WagnerFF.Rhesus base: D negative and DEL alleles. 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