{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T18:17:47Z","timestamp":1776363467126,"version":"3.51.2"},"reference-count":32,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2013,10,4]],"date-time":"2013-10-04T00:00:00Z","timestamp":1380844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Neonatal hemochromatosis (NH) is a rare disorder but the most common cause of acute liver failure in neonates. NH is characterized by severe hepatic injury and iron overload and is associated with high perinatal mortality and morbidity rates. NH is often preceded by oligohydramnios and intrauterine growth restriction, suggesting an important impact of NH during fetal life. Stillbirth and prematurity are not uncommon. During the last decade, major discoveries on the etiology of NH have radically changed the management and outcome of this disease. NH is now regarded as an alloimmune disease and is, as such, often referred to as gestational alloimmune liver disease. Antenatal treatment with intravenous immunoglobulins starting at 14\u2009weeks' gestation has been shown to prevent the development of NH in subsequent pregnancies. Postnatal treatment, previously based on the use of anti\u2010oxidants and chelation therapy, has now successfully been replaced by exchange transfusions and intravenous immunoglobulins substitution. This review summarizes the latest discoveries on the etiology of NH and the new recommendations concerning its management and prevention. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.4232","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T06:34:58Z","timestamp":1379054098000},"page":"1221-1225","source":"Crossref","is-referenced-by-count":60,"title":["Neonatal hemochromatosis: management, outcome, and prevention"],"prefix":"10.1002","volume":"33","author":[{"given":"Enrico","family":"Lopriore","sequence":"first","affiliation":[{"name":"Division of Neonatology and Gastroenterology, Department of Pediatrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Luisa","family":"Mearin","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Gastroenterology, Department of Pediatrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick","family":"Oepkes","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine, Department of Obstetrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Devlieger","sequence":"additional","affiliation":[{"name":"Division of Fetal Medicine, Department of Obstetrics Leuven University Medical Center  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter F.","family":"Whitington","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Lurie Children's Hospital of Chicago Research Center  Chicago IL 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