{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:43:49Z","timestamp":1785347029511,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2013,10,4]],"date-time":"2013-10-04T00:00:00Z","timestamp":1380844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to determine whether choroid plexus morphology (\u2018butterfly\u2019 sign) and biparietal diameter (BPD) are effective sonographic screening tools for holoprosencephaly (HPE) in the first trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An axial view of the fetal head was obtained routinely to determine the presence of the \u2018butterfly\u2019 sign in pregnancies presenting for sonographic screening at 11\u201313\u2009weeks of gestation. The same view was also used to obtain BPD measurements. The definitive diagnosis of HPE was established by the sonographic demonstration of an anterior cerebral monoventricular cavity and thalamic fusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a 9\u2010year study period, 11\u2009068 live fetuses were screened. There were 11 cases of HPE (prevalence 1\/1006); all of them were detected by demonstration of an absent \u2018butterfly\u2019 sign with no false\u2010positive cases. The BPD was less than the 5th percentile in 40% of the cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The \u2018butterfly\u2019 sign appears to be a highly sensitive marker for HPE in the first trimester. On the other hand, BPD measurements had a lower sensitivity, implying that microcephaly is not a prominent first\u2010trimester feature in these cases. Incorporation of the \u2018butterfly\u2019 sign into the first trimester anatomy scan is simple and can facilitate the identification of the vast majority of fetuses with HPE in the first trimester. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4235","type":"journal-article","created":{"date-parts":[[2013,9,10]],"date-time":"2013-09-10T07:14:16Z","timestamp":1378797256000},"page":"1233-1237","source":"Crossref","is-referenced-by-count":44,"title":["First trimester screening for holoprosencephaly with choroid plexus morphology (\u2018butterfly\u2019 sign) and biparietal diameter"],"prefix":"10.1002","volume":"33","author":[{"given":"Waldo","family":"Sepulveda","sequence":"first","affiliation":[{"name":"Fetal Medicine Center, Department of Obstetrics and Gynecology Clinica Las Condes  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Wong","sequence":"additional","affiliation":[{"name":"Fetal Medicine Center, Department of Obstetrics and Gynecology Clinica Las Condes  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,4]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"221","volume-title":"Diagnostic Imaging of Fetal Anomalies","author":"McGahan JP","year":"2003"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199805)18:5<477::AID-PD387>3.0.CO;2-J"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000263552"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00154.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1992.11.1.57"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1995.14.8.631"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13050356.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(99)00059-4"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13050360.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00005.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7646"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2004.23.6.761"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11280-6"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2637"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000259311.87056.5e"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2007.26.3.411"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2009.28.8.1077"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.162"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.093"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4143"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11175"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.05.014"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12420"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7484"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1992.02020088.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1994.04010065.x"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4235","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.4235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T10:32:07Z","timestamp":1698661927000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.4235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,4]]},"references-count":26,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1002\/pd.4235"],"URL":"https:\/\/doi.org\/10.1002\/pd.4235","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,4]]}}}