{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:37:04Z","timestamp":1780731424573,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T00:00:00Z","timestamp":1391644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the association between the use of medically assisted reproduction (MAR) and birth defects (BD) in newborns and terminations of pregnancy in pregnant women registered in Barcelona in the period 1992 to 2007.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 1905 cases and 2722 controls in a retrospective population\u2010based case\u2013control study. Cases comprised any newborn presenting at least one major BD, as well as any pregnancy terminated because of BD. Controls were newborns without BD. Exposure was MAR. Adjusted odds ratios (aOR) with 95% confidence intervals (CI) were calculated by means of logistic regression to assess the association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MAR was demonstrated to be associated with BD, after adjusting for probable confounders (aOR\u2009=\u20091.8; 95% CI\u2009=\u20091.4 to 2.5). Regarding MAR modalities, this association was statistically significant only for assisted reproduction techniques (ART) (aOR\u2009=\u20092.7; 95% CI\u2009=\u20091.8 to 4.1). In the stratified analysis by structural BD categories, frequencies for all categories were increased after ART with the exception of head\u2010face\u2010neck\u2010eye defects, none after artificial insemination, and digestive\u2010abdominal wall defects in ovulation induction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated a strong association between ART and BD, with an almost threefold increased risk for overall BD after ART, as compared with natural conception. Increased associations were also observed for almost all structural BD categories. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4286","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T21:19:01Z","timestamp":1385587141000},"page":"327-334","source":"Crossref","is-referenced-by-count":8,"title":["Birth defects in medically assisted reproduction pregnancies in the city of Barcelona"],"prefix":"10.1002","volume":"34","author":[{"given":"Rosa","family":"Gutarra\u2010Vilchez","sequence":"first","affiliation":[{"name":"Vitarte Hospital MINSA  Lima Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Santamari\u00f1a\u2010Rubio","sequence":"additional","affiliation":[{"name":"Servei de Sistemes d'Informaci\u00f3 Sanit\u00e0ria (SESIS). Ag\u00e8ncia de Salut P\u00fablica de Barcelona, CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Institut d'Investigaci\u00f3 Biom\u00e8dica (IIB Sant Pau)  Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Salvador","sequence":"additional","affiliation":[{"name":"Servei de Sistemes d'Informaci\u00f3 Sanit\u00e0ria (SESIS). Ag\u00e8ncia de Salut P\u00fablica de Barcelona, CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Institut d'Investigaci\u00f3 Biom\u00e8dica (IIB Sant Pau)  Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Borrell","sequence":"additional","affiliation":[{"name":"Department of Maternal\u2013Fetal Medicine Hospital Clinic de Barcelona  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,6]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.The global burden of disease: 2004 update. Ginebra 2008[WWW document]. URLwww.who.int\/es\/[accessed on 1 August 2009]."},{"key":"e_1_2_7_3_1","unstructured":"European Surveillance of Congenital Anomalies. \u2018Special report: the status of health in the European Union: congenital malformations\u2019 EUROCAT Central Registry University of Ulster 2009[WWW document]. URLhttp:\/\/www.eurocat\u2010network.eu\/[accessed on 1 August 2009]."},{"key":"e_1_2_7_4_1","unstructured":"SalvadorJ CunilleM RicardM RoigA. [Birth defects registry of the city of Barcelona (REDCB)] Annual Report2008[WWW document]. URLhttp:\/\/www.aspb.es\/quefem\/docs\/REDCB_WEB_2008.pdf[Accessed on 1 August 2009]."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3191"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-011-9583-z"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.09.009"},{"key":"e_1_2_7_8_1","unstructured":"FIVCAT.NET. [Information system on human reproduction] [WWW document]. Catalunya2008. URL:http:\/\/www.gencat.cat\/[Accessed on 1 August 2009]."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des023"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep035"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep098"},{"key":"e_1_2_7_12_1","first-page":"66","volume":"2","author":"Mart\u00ednez\u2010Fr\u00edas ML","year":"2006","journal-title":"Evid Pediatr"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep364"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38919.495718.AE"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)30527-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.1.256"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010035"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den387"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000279323"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.10.053"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.3.504"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.08.024"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh593"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-004-8760-8"},{"issue":"6","key":"e_1_2_7_25_1","first-page":"575","article-title":"Population\u2010based congenital birth defect registries in Spain","volume":"48","author":"Salvador J","year":"1998","journal-title":"An Esp Pediatr"},{"issue":"9","key":"e_1_2_7_26_1","first-page":"330","article-title":"The underreporting of perinatal mortality: 10 years' experience of active surveillance in Barcelona","volume":"108","author":"Ferrando J","year":"1997","journal-title":"Med Clin (Barc)"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms018"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008095"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.03.014"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.115123"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61621-5"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq258"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4286","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.4286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T01:10:04Z","timestamp":1696468204000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.4286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,6]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/pd.4286"],"URL":"https:\/\/doi.org\/10.1002\/pd.4286","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,6]]}}}